Turner syndrome and Cushing disease - the coexistence with overlapping complications: case report and literature review
| Autor: | Katarzyna Gniewek, Anna Brona, Katarzyna Kolackov, Marek Bolanowski, Diana Jędrzejuk |
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| Rok vydání: | 2019 |
| Předmět: |
Adenoma
Adult Pediatrics medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoporosis Myocardial Infarction Turner Syndrome Short stature Endocrinology Diabetes mellitus Turner syndrome medicine Humans Myocardial infarction Pituitary ACTH Hypersecretion business.industry Pituitary tumors Estrogen Replacement Therapy Obstetrics and Gynecology medicine.disease Cushing Disease ACTH-Secreting Pituitary Adenoma Diabetes Mellitus Type 2 Transgender hormone therapy Female medicine.symptom business Osteoporotic Fractures |
| Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 35(12) |
| ISSN: | 1473-0766 |
| Popis: | We present an unusual case of Turner syndrome (TS) and Cushing disease (CD) in a young woman, admitted to our department seven years after a successful surgical removal of ACTH-secreting pituitary tumor. To our knowledge, this is the first ever report of these two disorders coexisting. Our patient was diagnosed with TS at the age of 16 due to primary amenorrhea and short stature. Hormone replacement therapy with estrogen was initiated, but she did not receive growth hormone therapy. At the age of 28, she developed clinical and biochemical abnormalities consistent with hypercortisolism, but the definitive diagnosis of CD was established nine years later when she was admitted to our department. Appropriate treatment was applied, however, the patient developed serious complications: a myocardial infarction, diabetes and osteoporosis. Surgical treatment appeared to improve some, but not all of the symptoms, indicating a significant contribution of concomitant TS to the severity of adverse cardiovascular and bone turnover outcomes in a subject with a genetic susceptibility to these complications. Thus, multidisciplinary evaluation in such patients is strongly indicated, particularly if more predisposing conditions are present. |
| Databáze: | OpenAIRE |
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