Chlamydia trachomatis and Anti-MUC1 Serology and Subsequent Risk of High-Grade Serous Ovarian Cancer: A Population-Based Case–Control Study in Northern Sweden
| Autor: | Fredrik Elgh, Ulrika Ottander, Eva Lundin, Annika Idahl, Sarah Jonsson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Original article endocrine system Cancer Research medicine.medical_specialty endocrine system diseases Reproduktionsmedicin och gynekologi Population based medicine.disease_cause lcsh:RC254-282 Serology 03 medical and health sciences 0302 clinical medicine Obstetrics Gynecology and Reproductive Medicine Serous ovarian cancer medicine MUC1 Gynecology business.industry Case-control study Salpingitis medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens female genital diseases and pregnancy complications 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Chlamydia trachomatis business Fallopian tube |
| Zdroj: | Translational Oncology, Vol 13, Iss 1, Pp 86-91 (2020) Translational Oncology |
| ISSN: | 1936-5233 |
| Popis: | BACKGROUND: Chlamydia trachomatis salpingitis causes inflammatory damage to the fallopian tube and could potentially cause initiation and progression of high-grade serous ovarian cancer (HGSC). Furthermore, C. trachomatis infection may stimulate mucin 1 (MUC1) protein production, possibly affecting anti-MUC1 antibody levels. The aim of this study was to examine if serology indicating past infection with C. trachomatis as well as anti-MUC1 production was associated with subsequent risk of HGSC. MATERIALS AND METHODS: In a prospective nested case-control study within the Northern Sweden Health and Disease Study and the Northern Sweden Maternity Cohort, the prevalence of chlamydial and anti-MUC1 antibodies was analyzed in blood samples drawn more than one year before diagnosis from 92 women with HGSC and 359 matched controls. Matching factors were age, date at blood draw, and sampling cohort. Plasma C. trachomatis IgG was analyzed using commercial micro-immunofluorescence test; chlamydial Heat Shock Protein 60 IgG (cHSP60) and anti-MUC1 IgG were analyzed with ELISA technique. RESULTS: The prevalence of C. trachomatis IgG and cHSP60 IgG antibodies, as well as the level of anti-MUC1 IgG was similar in women with HGSC and controls (16.3% vs. 17.0%, P = 0.87; 27.2% vs. 28.5%, P = 0.80; median 0.24 vs. 0.25, P = 0.70). Anti-MUC1 IgG and cHSP60 IgG levels were correlated (r = 0.169; P |
| Databáze: | OpenAIRE |
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