Determinants of body weight regulation in humans
| Autor: | Cristiane Bauermann Leitão, Milene Moehlecke, Lucas Oliveira J. e Silva, Manoel Roberto Maciel Trindade, Rogério Friedman, Luis Henrique Santos Canani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism media_common.quotation_subject lcsh:Medicine 030209 endocrinology & metabolism Biology lcsh:Diseases of the endocrine glands. Clinical endocrinology Energy homeostasis 03 medical and health sciences body weight 0302 clinical medicine Weight loss Internal medicine Medical Illustration Appetite regulation energy metabolism energy expenditure medicine Humans Obesity Metabolismo energético media_common lcsh:RC648-665 Leptin lcsh:R Body Weight Appetite Peso corporal Neuropeptide Y receptor Regulação do apetite 030104 developmental biology Endocrinology Adipose Tissue Ghrelin Melanocortin medicine.symptom Energy Intake Energy Metabolism Hormone |
| Zdroj: | Archives of Endocrinology and Metabolism v.60 n.2 2016 Arquivos de Endocrinologia e Metabolismo Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM Archives of Endocrinology and Metabolism, Volume: 60, Issue: 2, Pages: 152-162, Published: 23 FEB 2016 Archives of Endocrinology and Metabolism, Vol 60, Iss 2, Pp 152-162 (2016) Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| Popis: | Body weight is regulated by the ability of hypothalamic neurons to orchestrate behavioral, endocrine and autonomic responses via afferent and efferent pathways to the brainstem and the periphery. Weight maintenance requires a balance between energy intake and energy expenditure. Although several components that participate in energy homeostasis have been identified, there is a need to know in more detail their actions as well as their interactions with environmental and psychosocial factors in the development of human obesity. In this review, we examine the role of systemic mediators such as leptin, ghrelin and insulin, which act in the central nervous system by activating or inhibiting neuropeptide Y, Agouti-related peptide protein, melanocortin, transcript related to cocaine and amphetamine, and others. As a result, modifications in energy homeostasis occur through regulation of appetite and energy expenditure. We also examine compensatory changes in the circulating levels of several peripheral hormones after diet-induced weight loss. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|