A relative resistance of T cells to dexamethasone in bipolar disorder
| Autor: | M. Nadine Breunis, Marielle C. van Geest, Harm de Wit, Hemmo A. Drexhage, Esther M. Knijff, Cindy Ruwhof, Willem A. Nolen, Ralph Kupka |
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| Přispěvatelé: | Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Immunology, General Practice, Human genetics |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty MOOD DISORDERS CD3 Complex T-Lymphocytes SUPPRESSION TEST T cells LYMPHOCYTE SENSITIVITY dexamethasone MEDIATED-IMMUNITY Lymphocyte Activation Severity of Illness Index resistance Immune system GLUCOCORTICOID-RECEPTOR GENE Internal medicine medicine Humans Bipolar disorder IL-2 receptor MANIC PATIENTS Glucocorticoids Biological Psychiatry Dexamethasone Cells Cultured Ultradian rhythm bipolar disorder MAJOR DEPRESSIVE DISORDER Chemistry Interleukin-2 Receptor alpha Subunit LITHIUM TREATMENT Middle Aged medicine.disease In vitro Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Endocrinology Mood disorders HORMONE TEST Major depressive disorder Female PITUITARY-ADRENAL AXIS medicine.drug |
| Zdroj: | Bipolar Disorders, 8(6), 740-750. Wiley Knijff, E M, Breunis, M N, van Geest, M C, Kupka, R W, Ruwhof, C, de Wit, H J, Nolen, W A & Drexhage, H A 2006, ' A relative resistance of T cells to dexamethasone in bipolar disorder ', Bipolar Disorders, vol. 8, no. 6, pp. 740-750 . https://doi.org/10.1111/j.1399-5618.2006.00359.x Bipolar Disorders, 8(6), 740-750. Blackwell Publishing Bipolar Disorders, 8(6), 740-750. Blackwell Munksgaard |
| ISSN: | 1398-5647 |
| DOI: | 10.1111/j.1399-5618.2006.00359.x |
| Popis: | Objective: A relative resistance of immune cells to steroids has been established in patients with major depression (MD). In this study, we investigated the in vitro responsiveness of T cells to dexamethasone (DEX) of patients with bipolar disorder (BD). Methods: T cells of outpatients with DSM-IV BD (n = 54) and of healthy control subjects (HC; n = 29) were isolated, cultured and stimulated with phytohemagglutinin (PHA) for 72 h. The suppressive effect of graded concentrations of DEX (5 × 10-9-10-5 M) on PHA-induced CD25 (IL-2R) expression was measured by fluorescence-activated cell sorting (FACS) analysis. Data were correlated to the T-cell activation status in the peripheral blood of the same patients and to their diagnosis, current mood state, ultradian cycling pattern and current use of medication, including lithium. Results: T cells of patients with BD were less sensitive to DEX-induced suppressive effects as compared with T cells of HC. These data were particularly evident at 10-7 M DEX (mean % suppression ± SEM BD: 18.9% ± 3.5 versus HC: 35.8% ± 4.7, p = 0.001). We found no correlations of this relative in vitro DEX resistance of T cells neither with the previously mentioned clinical characteristics nor with the actual activation status of the T cells in the BD patients. Conclusion: A relative T-cell resistance to steroids, as has been observed in MD previously, may be a trait phenomenon of BD, independent of mood state. |
| Databáze: | OpenAIRE |
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