Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects
| Autor: | Noyan Gokce, Mitali S. Shah, Ashley C. Bourland, Kerrie P. Nelson, Nawfal W. Istfan, Caroline M. Apovian, Megan R. Ruth, Ava Port |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Calorie Endocrinology Diabetes and Metabolism Blood lipids Diet High-Fat Article Body Mass Index chemistry.chemical_compound Diet Carbohydrate-Restricted Endocrinology High-density lipoprotein Weight loss Internal medicine Weight Loss medicine Humans Obesity Caloric Restriction Inflammation Glucose tolerance test medicine.diagnostic_test Triglyceride Adiponectin Anthropometry Cholesterol HDL Hemodynamics Glucose Tolerance Test Middle Aged medicine.disease Vasodilation C-Reactive Protein chemistry Adipose Tissue Body Composition Patient Compliance Female medicine.symptom Lipoproteins HDL |
| Zdroj: | Metabolism: clinical and experimental. 62(12) |
| ISSN: | 1532-8600 |
| Popis: | Objective High fat, low carbohydrate (HFLC) diets have become popular tools for weight management. We sought to determine the effects of a HFLC diet compared to a low fat high carbohydrate (LFHC) diet on the change in weight loss, cardiovascular risk factors and inflammation in subjects with obesity. Methods Obese subjects (29.0–44.6kg/m 2 ) recruited from Boston Medical Center were randomized to a hypocaloric LFHC (n=26) or HFLC (n=29) diet for 12weeks. Results The age range of subjects was 21–62years. As a percentage of daily calories, the HFLC group consumed 33.5% protein, 56.0% fat and 9.6% carbohydrate and the LFHC group consumed 22.0% protein, 25.0% fat and 55.7% carbohydrate. The change in percent body weight, lean and fat mass, blood pressure, flow mediated dilation, hip:waist ratio, hemoglobin A1C, fasting insulin and glucose, and glucose and insulin response to a 2h oral glucose tolerance test did not differ (P>0.05) between diets after 12weeks. The HFLC group had greater mean decreases in serum triglyceride (P=0.07), and hs-CRP (P=0.03), and greater mean increases in HDL cholesterol (P=0.004), and total adiponectin (P=0.045) relative to the LFHC. Secreted adipose tissue adiponectin or TNF- α did not differ after weight loss for either diet. Conclusions Relative to the LFHC group, the HFLC group had greater improvements in blood lipids and systemic inflammation with similar changes in body weight and composition. This small-scale study suggests that HFLC diets may be more beneficial to cardiovascular health and inflammation in free-living obese adults compared to LFHC diets. |
| Databáze: | OpenAIRE |
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