Cytogenetic and interphase Fluorescence in Situ Hybridization studies in patients with multiple myeloma
| Autor: | N Indhumathi, Anil Tarigopula, G Perumal, P Prabu, RS Chandra, Rama Mani |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Biochemistry
medical Plasma cell leukemia medicine.medical_specialty medicine.diagnostic_test Biochemistry (medical) Cytogenetics Plasma cell Biology Bioinformatics medicine.disease Biochemistry medicine.anatomical_structure Poster Presentation Genetics medicine Cancer research Molecular Medicine Genetics(clinical) Interphase Bone marrow Molecular Biology Genetics (clinical) Multiple myeloma Monoclonal gammopathy of undetermined significance Fluorescence in situ hybridization |
| Zdroj: | Molecular Cytogenetics |
| ISSN: | 1755-8166 |
| Popis: | Background Multiple myeloma (MM) is characterized by the clonal proliferation and accumulation of malignant plasma cells in the bone marrow, monoclonal protein in the blood or urine and associated organ dysfunction. Some patients may show a slow progressive evolution from monoclonal gammopathy of undetermined significance while others may be associated with features of high clonal aggressiveness such as plasma cell leukemia or extramedullary plasmacytomas. Chromosomal abnormalities (mainly IgH translocations and trisomies) have been shown to be of prognostic significance in MM. Interphase fluorescence in situ hybridization (i-FISH), in particular, has been much more effective in identifying these trisomies/ monosomies and specific translocations. |
| Databáze: | OpenAIRE |
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