Cell type-dependent effects of ellagic acid on cellular metabolism
| Autor: | Erica L. Underwood, Darren Boehning, Safia A. Essien, Alexandra L. Boehning, Pramod K. Dash |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Programmed cell death Time Factors Cellular respiration Cell Apoptosis Mitochondrion Article HeLa 03 medical and health sciences chemistry.chemical_compound Adenosine Triphosphate 0302 clinical medicine Ellagic Acid Neoplasms medicine Humans Membrane Potential Mitochondrial Pharmacology Caspase 6 Dose-Response Relationship Drug biology Caspase 3 Chemistry Hep G2 Cells General Medicine biology.organism_classification Antineoplastic Agents Phytogenic Mitochondria Metabolic pathway HEK293 Cells 030104 developmental biology medicine.anatomical_structure Biochemistry Polyphenol 030220 oncology & carcinogenesis MCF-7 Cells Energy Metabolism HeLa Cells Ellagic acid |
| Zdroj: | Biomedicine & Pharmacotherapy. 106:411-418 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2018.06.142 |
| Popis: | Ellagic acid is a botanical polyphenol which has been shown to have numerous effects on cellular function. Ellagic acid can induce apoptosis and inhibit the proliferation of various cancer cell types in vitro and in vivo. As such, ellagic acid has attracted significant interest as a potential chemotherapeutic compound. One mechanism by which ellagic acid has been proposed to affect cellular physiology is by regulating metabolic pathways. Here we show the dose-dependent effects of ellagic acid on cellular energy production and downstream induction of the apoptotic program in HEK293, HeLa, MCF7, and HepG2 cells. At physiologically relevant doses, eallgic acid has pleiotropic and cell-type specific effects on mitochondrial function. At high doses ellagic acid can also influence glycolytic pathways and induce cell death. Our results demonstrate that ellagic acid can influence mitochondrial function at therapeutically relevant concentrations. The observed effects of ellagic acid on cellular respiration are complex and cell type-specific, which may limit the chemotherapeutic utility of this compound. |
| Databáze: | OpenAIRE |
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