Blockade of β1- and desensitization of β2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis
| Autor: | Naïma Hanoun, Fazia Brouri, Françoise Saurini, Paul M. Vanhoutte, Odile Médiani, Philippe Lechat, Michel Hamon |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class Cardiac fibrosis Heart Ventricles Adrenergic beta-2 Receptor Antagonists Fibrosis Isoprenaline Internal medicine medicine Animals Albuterol Rats Wistar Adrenergic beta-2 Receptor Agonists Pharmacology Dose-Response Relationship Drug Ventricular Remodeling business.industry Myocardium Isoproterenol Antagonist medicine.disease Adrenergic beta-1 Receptor Antagonists Rats Endocrinology Adrenergic beta-1 Receptor Agonists Bisoprolol Circulatory system Salbutamol Receptors Adrenergic beta-2 Receptors Adrenergic beta-1 business medicine.drug |
| Zdroj: | European Journal of Pharmacology. 485:227-234 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2003.11.063 |
| Popis: | The aim of the present study was to analyse the role of beta(1)- and beta(2)-adrenoceptors in the catecholamine-induced myocardial remodeling, especially the interstitial fibrosis. Wistar rats were subjected to a 2-week chronic isoprenaline administration (30 microg/kg/h). Rats received a concomitant treatment with the selective beta(1)-adrenoceptor antagonist, bisoprolol (50 mg/kg/day p.o.) or were chronically pretreated with the selective beta(2)-adrenoceptor agonist salbutamol (40 microg/kg/h) for 1 week to induce beta(2)-adrenoceptor desensitization. The pretreatment with salbutamol induced a 59% down-regulation of left ventricular beta(2)-adrenoceptors compared to control. The extent of the isoprenaline-induced left ventricular fibrosis was significantly reduced in both the bisoprolol and salbutamol groups compared with the control isoprenaline-treated group especially in the apical region (1.7+/-0.6% and 1.4+/-0.3% versus 6.0+/-1.3%, respectively, P0.005). beta(1)-adrenoceptor blockade and beta(2)-adrenoceptors down-regulation provided similar protection against isoprenaline-induced cardiac interstitial fibrosis suggesting that both beta-adrenoceptors are involved in such cardiac remodeling process. |
| Databáze: | OpenAIRE |
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