Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations
| Autor: | Danielle I. McCarthy, Rosalind J. Miller, Leanne Smith, Jonathan A. Farrimond, Monica L Castro-Acosta, Wendy L. Hall |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Blood Glucose Male Tmax Time of maximum concentration medicine.medical_treatment Endocrinology Diabetes and Metabolism Clinical Biochemistry Biochemistry Anthocyanins chemistry.chemical_compound Diet Carbohydrate-Restricted Ribes CON Control treatment Functional Food Insulin NEFA Non-esterified fatty acids GLP-1 Glucagon-like peptide-1 M-BE Medium dose off blackcurrant extract Meals TAG Triacylglycerol Meal Cross-Over Studies Nutrition and Dietetics DVP-RI Digital volume pulse reflection index Berries Postprandial glycemia Middle Aged Postprandial Period Glucagon-like peptide-1 Clinical trial Postprandial Randomized controlled trial AOB Area over baseline Female Diet Carbohydrate Loading Research Article Adult medicine.medical_specialty Incretin Incretins Beverages 03 medical and health sciences NEFA Double-Blind Method L-BE Low dose of blackcurrant extract Internal medicine Hyperinsulinism medicine Cmax Maximum concentration Humans Hypoglycemic Agents GIP Glucose-dependent insulinotropic polypeptide Healthy volunteers Molecular Biology 030109 nutrition & dietetics Plant Extracts Polyphenols Crossover study Endocrinology Glucose chemistry Anthocyanin Fruit Hyperglycemia H-BE High dose of blackcurrant extract DVP-SI Digital volume pulse stiffness index |
| Zdroj: | The Journal of Nutritional Biochemistry Acosta, M L C, Smith, L, Miller, R J, McCarthy, D I, Farrimond, J A & Hall, W L 2016, ' Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations ', JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 38, pp. 154-161 . https://doi.org/10.1016/j.jnutbio.2016.09.002 |
| ISSN: | 0955-2863 |
| DOI: | 10.1016/j.jnutbio.2016.09.002 |
| Popis: | Blackcurrants are rich in polyphenolic glycosides called anthocyanins, which may inhibit postprandial glycemia. The aim was to determine the dose-dependent effects of blackcurrant extract on postprandial glycemia. Men and postmenopausal women (14 M, 9 W, mean age 46 y, SD 14) were enrolled into a randomized, double-blind, crossover trial. Low sugar fruit drinks containing blackcurrant extract providing150 mg (L-BE), 300 mg (M-BE) and 600 mg (H-BE) total anthocyanins or no blackcurrant extract (CON) were administered immediately before a high-carbohydrate meal. Plasma glucose, insulin, and incretins (GIP and GLP-1) were measured 0-120 min, and plasma 8-isoprostane F2α, together with arterial stiffness by digital volume pulse (DVP) were measured at 0 and 120 min. Early plasma glucose response was significantly reduced following H-BE (n = 22), relative to CON, with a mean difference (95% CI) in area over baseline (AOB) 0-30min of -0.34 mmol/L.h (-0.56, -0.11, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect