Polyamine biosynthesis and accumulation during the early development of the nudibranch Phestilla sibogae
| Autor: | Michael G. Hadfield, Diane Haddock Russell, Carol-Ann Manen |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adenosylmethionine Decarboxylase
Spermidine Ornithine Decarboxylase chemistry.chemical_compound Methionine decarboxylase activity Polyamines Putrescine Animals Polyamine biosynthesis Molecular Biology biology Embryogenesis Age Factors Cell Biology Nudibranch biology.organism_classification Enzyme Activation Phestilla sibogae Biochemistry chemistry Mollusca Larva Polyamine Developmental Biology |
| Zdroj: | Developmental Biology. 57:454-459 |
| ISSN: | 0012-1606 |
| DOI: | 10.1016/0012-1606(77)90230-5 |
| Popis: | Polyamine biosynthesis and accumulation were studied during the early development of the nudibranch Phestilla sibogae. Ornithine decarboxylase activity increases over 40-fold in the first 4 days of embryogenesis, with the maximum (400 pmole of 14CO2/30 min/mg of protein) occurring between Days 3 and 4, the time of most rapid growth. Putrescine-stimulated S-adenosyl- l -methionine decarboxylase activity is not detectable until the second day of development and attains maximal activity (100 pmole of 14CO2/30 min/mg of protein) at Day 4. The pattern of spermidine-stimulated S-adenosyl- l -methionine decarboxylase activity is similar. Putrescine and spermidine double in concentration between Days 0 and 6. Adults contain fairly high levels of putrescine and spermidine, similar to prokaryotes. The increase in the polyamine biosynthetic enzymes and the accumulation patterns of the polyamines correlate well with data from other early developmental systems and support the hypothesis of key roles for the polyamine pathway in the control of growth processes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|