Extraction socket grafting using Recombinant human bone morphogenetic protein-2 -Clinical implications and histological observations
| Autor: | Gayatri Ragit, Vidya Sudhindra Baliga, Khushboo Jeevan Durge, Prasad V Dhadse, Shilpa Bangalore Sridhar |
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| Rok vydání: | 2020 |
| Předmět: |
Radiography
Grafting (decision trees) 0206 medical engineering Human bone Dentistry lcsh:Medicine Bone Morphogenetic Protein 2 02 engineering and technology Bone morphogenetic protein General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Transforming Growth Factor beta Medicine Humans Tooth Socket lcsh:Science (General) lcsh:QH301-705.5 Dental Implants Crestal bone business.industry Extraction (chemistry) lcsh:R 030206 dentistry General Medicine 020601 biomedical engineering Recombinant Proteins Implant placement Research Note lcsh:Biology (General) Pine wood Tooth Extraction business lcsh:Q1-390 |
| Zdroj: | BMC Research Notes BMC Research Notes, Vol 14, Iss 1, Pp 1-6 (2021) |
| Popis: | Objectives Rehabilitation of edentulous ridges to promote the insertion of dental implants has been the key indicator for retaining osseous structures since tooth extraction. Recombinant Bone Morphogenetic Protein-2(rhBMP-2) is exploited for bone augmentation due to its osteoinductive capacity. The objective of the study to determine the effectiveness of bone induction for implant placement by rhBMP-2 delivered on beta-tricalcium phosphate graft (β-TCP) and PRF following tooth extraction. Results Minimal changes in the width of the crestal bone relative to baseline values were found three months after socket grafting. A bone loss in the mesiodistal and buccolingual aspects of 0.6 ± 0.13 mm and 0.5 ± 0.13 mm was found, respectively. While drilling before the implant placement, the bone's clinical hardness evaluated through tactile was analogous to drilling into spruce or white pine wood. Total radiographic bone filling was seen in 3 months and no additional augmentation was needed during implant placement. Besides, histology shows no residual graft of bone particles. Therefore, the data from this study demonstrated that the novel combination of rhBMP-2 + β-TCP mixed with PRF has an effect on de novo bone formation and can be recommended for socket grafting before implant placement. |
| Databáze: | OpenAIRE |
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