A Novel Small Animal Model of Norovirus Diarrhea
| Autor: | Sourish Ghosh, Nihal Altan-Bonnet, Smith Jc, Kirsche E, Alexa N. Roth, Stephanie M. Karst, Carmen Mirabelli, Laura B. Eurell, Emily W. Helm, Christiane E. Wobus |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Systemic disease
viruses ved/biology.organism_classification_rank.species Disease medicine.disease_cause 03 medical and health sciences Dual role fluids and secretions Disease severity Small animal medicine 030304 developmental biology 0303 health sciences 030306 microbiology business.industry ved/biology virus diseases medicine.disease digestive system diseases 3. Good health Diarrhea Immunology Norovirus medicine.symptom business Murine norovirus |
| DOI: | 10.1101/2020.03.19.999185 |
| Popis: | Human noroviruses are the leading cause of severe childhood diarrhea worldwide yet we know very little about their pathogenic mechanisms. Murine noroviruses cause diarrhea in interferon-deficient adult mice but these hosts also develop systemic pathology and lethality, reducing confidence in the translatability of findings to human norovirus disease. Herein we report that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice, thus mirroring the key features of human norovirus disease and representing a robust norovirus small animal disease model. Intriguingly, lymphocytes are critical for controlling acute norovirus replication while simultaneously contributing to disease severity, likely reflecting their dual role as targets of viral infection and key components of the host response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|