Oral Squamous Cell Carcinoma Mimicking Medication-Related Osteonecrosis of the Jaws (MRONJ): A Case Series
| Autor: | Rodolfo Mauceri, Corrado Toro, Giuseppina Campisi, Martina Iurato Carbone, Vera Panzarella, Vito Rodolico |
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| Přispěvatelé: | Rodolfo Mauceri, Corrado Toro, Vera Panzarella, Martina Iurato Carbone, Vito Rodolico, Giuseppina Campisi |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Osteoporosis ONJ Physical examination RK1-715 Dehiscence medicine.disease MRONJ Dermatology Oral Squamous Cell Carcinoma Medication-Related Osteonecrosis of the Jaws MRONJ Case Series oral squamous cell carcinoma stomatognathic diseases osteonecrosis of the jaw Radiological weapon Dentistry medicine bone exposure In patient Basal cell OSCC Osteonecrosis of the jaw business Adverse drug reaction |
| Zdroj: | Oral, Vol 1, Iss 32, Pp 326-331 (2021) |
| Popis: | (1) Background: Medication-related osteonecrosis of the jaw (MRONJ) is a potential adverse drug reaction of antiresorptive and/or antiangiogenic treatment. MRONJ is mostly diagnosed by anamnestic data, clinical examination and radiological findings, with signs and symptoms often unspecific. On the other hand, oral squamous cell carcinoma (OSCC) is characteristic for its pleomorphic appearance (e.g., ulcer, mucous dehiscence, non-healing post-extractive socket). We report three cases where OSCC mimicked MRONJ lesions. (2) Patients: Three patients undergoing amino-bisphosphonate treatment for osteoporosis presented with areas of intraorally exposed jawbone and unspecific radiological signs compatible with MRONJ. Due to the clinical suspicious of malignant lesion, incisional biopsy for histological examination was also performed. (3) Results: Histological examination of the tissue specimen revealed the presence of OSCC. All patients underwent cancer treatment. (4) Conclusions: Several signs and symptoms of OSCC may simulate, in patients with a history of anti-resorptive, MRONJ; for these reasons, it is important to perform histologic analysis when clinicians are facing a suspicious malignant lesion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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