Aortic baroreceptor function and depressed baroreflex sensitivity following myocardial infarction
| Autor: | Hong Jeong, M. Susan Quinn, Anthony J. Minisi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Baroreceptor Myocardial Infarction Blood Pressure Pressoreceptors Baroreflex Autonomic Nervous System Cellular and Molecular Neuroscience Dogs Heart Conduction System Heart Rate Internal medicine Heart rate medicine Animals Myocardial infarction Phenylephrine Aorta Endocrine and Autonomic Systems business.industry Reflex arc fungi Baroreceptor function medicine.disease Disease Models Animal Blood pressure medicine.anatomical_structure Anesthesia cardiovascular system Cardiology Neurology (clinical) business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Autonomic Neuroscience. 150:33-37 |
| ISSN: | 1566-0702 |
| Popis: | Depressed sinoaortic baroreflex control of heart rate following myocardial infarction (MI) is associated with increased morbidity and mortality. The etiology of this autonomic disturbance is unknown but could potentially occur at several levels of the reflex arc. The purpose of this study was to assess whether depressed baroreflex sensitivity (BRS) post-MI is associated with aortic baroreceptor dysfunction. BRS was measured before and 4–8 weeks after anterior MI in 17 chronically-instrumented, trained, conscious dogs. BRS (ms/mm Hg) was defined as the slope of the relationship between changes in systolic blood pressure (SBP) and heart period in response to a bolus dose of phenylephrine (PE). After the effects of MI on BRS were determined, the animals were anesthetized and the aortic depressor nerves (ADN) were isolated from the cervical vagi. Aortic baroreceptor function was measured by direct recording of ADN activity during gradual elevation of SBP induced by PE infusion. BRS was depressed following MI in 7 of these dogs and preserved in the remaining 10. Aortic baroreceptor sensitivity (ABS) defined as the slope of the relationship between changes in ADN activity and SBP was not significantly different between the dogs with depressed BRS compared to the dogs with preserved BRS post-MI. In conclusion, the response of the aortic baroreceptors to an increase in SBP is similar in dogs with and without depressed BRS post-MI. Based on these data, we conclude that depressed reflex control of heart rate following MI is not related to dysfunction of the afferent limb of the sinoaortic baroreflex. |
| Databáze: | OpenAIRE |
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