A Structural Perspective on the Where, How, Why, and What of Nucleosome Positioning
| Autor: | Sergei A. Grigoryev, Gaurav Arya, Arijit Maitra |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Genetics
Base Sequence biology General Medicine Computational biology Solenoid (DNA) Chromatin Assembly and Disassembly Linker DNA Enzymes Nucleosomes Histone Structural Biology Histone methylation Chromatosome biology.protein Animals Humans Nucleic Acid Conformation Nucleosome Histone code Histone octamer Molecular Biology |
| Zdroj: | Journal of Biomolecular Structure and Dynamics. 27:803-820 |
| ISSN: | 1538-0254 0739-1102 |
| DOI: | 10.1080/07391102.2010.10508585 |
| Popis: | The DNA in eukaryotic chromatin is packed by histones into arrays of repeating units called nucleosomes. Each nucleosome contains a nucleosome core, where the DNA is wrapped around a histone octamer, and a stretch of relatively unconstrained DNA called the linker DNA. Since nucleosome cores occlude the DNA from many DNA-binding factors, their positions provide important clues for understanding chromatin packing and gene regulation. Here we review the recent advances in the genome-wide mapping of nucleosome positions, the molecular and structural determinants of nucleosome positioning, and the importance of nucleosome positioning in chromatin higher order folding and transcriptional regulation. |
| Databáze: | OpenAIRE |
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