Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders
| Autor: | Silke Miller, Maria-Jesus Blanco |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology Innate immune system Microglia business.industry Organic Chemistry Pharmaceutical Science Biochemistry Small molecule Chemistry 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure nervous system Drug Discovery medicine Molecular Medicine business Neuroscience 030217 neurology & neurosurgery Neuroinflammation |
| Zdroj: | RSC Med Chem |
| ISSN: | 2632-8682 |
| DOI: | 10.1039/d1md00036e |
| Popis: | Chronically activated microglia and the resulting cascade of neuroinflammatory mechanisms have been postulated to play a critical role in neurodegenerative disorders. Microglia are the main component of the brain's innate immune system and become activated by infection, injury, misfolded proteins or a multitude of other stimuli. Activated microglia release pro-inflammatory and cytotoxic factors that can damage neurons and transform astrocytes to become toxic to neurons as well. Therapeutic approaches aiming to modulate microglia activation may be beneficial to mitigate the progression of inflammatory-mediated neurodegenerative diseases. In this literature review, we provide an overview of recent progress on key microglia targets and discovery of small molecule compounds advancing in clinical trials to minimize neuroinflammation. |
| Databáze: | OpenAIRE |
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