Differentiation of B16 murine melanoma cells is associated with an increased level of c-SRC
| Autor: | O'Connor Tj, Fujita Dj |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
Skin Neoplasms Proto-Oncogene Proteins pp60(c-src) Melanoma Experimental Retinoic acid Tretinoin Dermatology Mice chemistry.chemical_compound Melanocyte differentiation Tumor Cells Cultured medicine Animals RNA Neoplasm neoplasms Messenger RNA Melanoma Cell Differentiation 3T3 Cells Fibroblasts medicine.disease Oncology chemistry Cell culture Cancer research Melanocytes Function (biology) B16 melanoma Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | Melanoma Research. 5:5-13 |
| ISSN: | 0960-8931 |
| DOI: | 10.1097/00008390-199502000-00002 |
| Popis: | Elevated levels of c-SRC activity have been found in human melanocytes and some human melanoma cell lines. We examined c-SRC in B16 murine melanoma cells. B16-F0 non-metastatic melanoma cells contained threefold more c-SRC activity and protein than NIH 3T3 murine fibroblasts. Differentiation of B16-F1 metastatic melanoma cells with retinoic acid resulted in an elevation in c-SRC activity, protein and mRNA. The increase in c-SRC was detectable after about 48 h of retinoic acid treatment, as were changes in cellular morphology and growth rate. Thus, there is a correlation between differentiation and expression of c-SRC in B16 murine melanoma cells. These findings suggest a role for c-SRC in murine melanocyte differentiation or function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|