Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor
| Autor: | Laurence Preisser, Alain Morel, Fabien Barbier, Odile deLapeyrière, Jacques Hermann, Damien Derouet, Maud Barbado, Hugues Gascan, Josy Froger, François Rousseau, Fabienne Alfonsi, David Perret, Agnès Dumont, Catherine Guillet, Sylvie Chevalier, Caroline Diveu |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Molecular Sequence Data
Leukemia inhibitory factor receptor Ciliary neurotrophic factor Fibroblast growth factor Polymerase Chain Reaction Mice Epidermal growth factor Sequence Homology Nucleic Acid Animals Humans Amino Acid Sequence Interleukin 6 Receptor Ciliary Neurotrophic Factor Multidisciplinary biology Base Sequence Sequence Homology Amino Acid Interleukin-6 DNA Biological Sciences Glycoprotein 130 Molecular biology biology.protein Ciliary neurotrophic factor receptor Signal transduction Protein Binding Signal Transduction |
| Popis: | A structural profile-based computational screen was used to identify neuropoietin (NP), a new cytokine. The np gene is localized in tandem with the cardiotrophin - 1 gene on mouse chromosome 7. NP shares structural and functional features with ciliary neurotrophic factor (CNTF), cardiotrophin-1, and cardiotrophin-like cytokine. It acts through a membrane receptor complex comprising CNTF receptor-α component (CNTFRα), gp130, and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling pathway. NP is highly expressed in embryonic neuroepithelia. Strikingly, CNTFRα, but not its alternate ligands, CNTF and cardiotrophin-like cytokine, is expressed at the same developmental stages. NP is also observed in retina and to a lesser extent in skeletal muscle. Moreover, NP could sustain the in vitro survival of embryonic motor neurons and could increase the proliferation of neural precursors when associated to epidermal growth factor and fibroblast growth factor 2. Thus, NP is a new ligand for CNTFRα, with important implications for murine nervous system development. |
| Databáze: | OpenAIRE |
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