A Biostable l ‐DNA Hydrogel with Improved Stability for Biomedical Applications
| Autor: | Bo Yang, Bini Zhou, Cuifeng Li, Xiaowei Li, Ziwei Shi, Yuxin Li, Chenyou Zhu, Xin Li, Yi Hua, Yufan Pan, Jian He, Tianyang Cao, Yawei Sun, Wanli Liu, Min Ge, Yuhe R. Yang, Yuanchen Dong, Dongsheng Liu |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Angewandte Chemie. 134 |
| ISSN: | 1521-3757 0044-8249 |
| DOI: | 10.1002/ange.202202520 |
| Popis: | DNA hydrogels have attracted increasing attention owing to their excellent permeability and high mechanical strength, together with thixotropy, versatile programmability and good biocompatibility. However, the moderate biostability and immune stimulation of DNA have arisen as big concerns for future potential clinical applications. Herein, we report the self-assembly of a novel l-DNA hydrogel, which inherited the extraordinary physical properties of a d-DNA hydrogel. With the mirror-isomer deoxyribose, this hydrogel exhibited improved biostability, withstanding fetal bovine serum (FBS) for at least 1 month without evident decay of its mechanical properties. The low inflammatory response of the l-DNA hydrogel has been verified both in vitro and in vivo. Hence, this l-DNA hydrogel with outstanding biostability and biocompatibility can be anticipated to serve as an ideal 3D cell-culture matrix and implanted bio-scaffold for long-term biomedical applications. |
| Databáze: | OpenAIRE |
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