High-intensity interval training improved fasting blood glucose and lipid profiles in type 2 diabetic rats more than endurance training; possible involvement of irisin and betatrophin
| Autor: | Seied Amirhossein Latifi, Mohammad Parastesh, Mona Alaee, Jamal Amri, Mehdi Sadegh |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Betatrophin medicine.medical_treatment 030209 endocrinology & metabolism High-Intensity Interval Training Interval training Diabetes Mellitus Experimental 03 medical and health sciences 0302 clinical medicine Angiopoietin-Like Protein 8 Endurance training Physical Conditioning Animal Physiology (medical) Internal medicine medicine Animals Insulin Rats Wistar business.industry Body Weight Fasting Lipids Fibronectins Rats Endurance Training Angiopoietin-like Proteins 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 business High-intensity interval training |
| Zdroj: | Physiology International. 106:213-224 |
| ISSN: | 2498-602X |
| Popis: | Background and aims In this study, we aimed to investigate the effects of 10 weeks of high-intensity interval training (HIIT) and endurance training (END) on irisin, betatrophin, insulin, fasting blood glucose (FBG) concentrations, and lipid profiles in diabetic rats. Methods Twenty-four Wistar rats (weight: 200–250 g) were randomly assigned into four groups as follows: (1) control (Cnt), (2) diabetic (Dibt), (3) diabetic HIIT (Dibt-HIIT), and (4) diabetic END (Dibt-END). For inducing diabetes, after 12 h of food starvation, nicotinamide (120 mg/kg) and streptozotocin (STZ; 65 mg/kg) were intraperitoneally injected. The diabetic training groups received 10 weeks of HIIT or END training following the induction of diabetes. Twenty-four hours following the last training session, blood serum samples were collected for evaluating the concentration of irisin, betatrophin, and insulin hormones through enzyme-linked immunosorbent assay. Results FBG and lipid profiles were measured by biochemical kits. A significant increase in the serum concentration of irisin (p p p P p p Conclusions It seems that HIIT leads to a more extensive improvement in diabetic conditions compared to the END training. Therefore, HIIT appears to be an important time-efficient approach for the treatment of type 2 diabetes. |
| Databáze: | OpenAIRE |
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