HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau: a retrospective cross-sectional hospital study
| Autor: | Noel Vieira, Dlama Nggida Rasmussen, Morten Bjerregaard-Andersen, Sanne Jespersen, Christian Wejse, Inés Oliveira, Bo Langhoff Hønge, David da Silva Té, Holger W. Unger, Morten Sodemann, Alcino Furtado, Magarida Alfredo Gomes |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Epidemiology Cross-sectional study Ethnic group Human immunodeficiency virus (HIV) HIV Infections wc_503 medicine.disease_cause 0302 clinical medicine Pregnancy Risk Factors Prevalence Guinea-Bissau wq_200 030212 general & internal medicine Young adult Multidisciplinary Transmission (medicine) Obstetrics virus diseases Middle Aged Hospitals Anti-Retroviral Agents Medicine Female medicine.symptom Adult medicine.medical_specialty Adolescent Science wa_395 wa_310 Article Young Adult 03 medical and health sciences medicine Humans Retrospective Studies business.industry Infant Newborn Retrospective cohort study Infant Low Birth Weight medicine.disease 030112 virology Infectious Disease Transmission Vertical Low birth weight Cross-Sectional Studies HIV-2 HIV-1 business |
| Zdroj: | Rasmussen, D N, Vieira, N, Hønge, B L, da Silva Té, D, Jespersen, S, Bjerregaard-Andersen, M, Oliveira, I, Furtado, A, Gomes, M A, Sodemann, M, Wejse, C & Unger, H W 2020, ' HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau : a retrospective cross-sectional hospital study ', Scientific Reports, vol. 10, 12174 . https://doi.org/10.1038/s41598-020-68806-5 Rasmussen, D N, Vieira, N, Hønge, B L, da Silva Té, D, Jespersen, S, Bjerregaard-Andersen, M, Oliveira, I, Furtado, A, Gomes, M A, Sodemann, M, Wejse, C & Unger, H W 2020, ' HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau : a retrospective cross-sectional hospital study ', Scientific Reports, vol. 10, no. 1, 12174 . https://doi.org/10.1038/s41598-020-68806-5 Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-68806-5 |
| Popis: | The human immunodeficiency virus (HIV) remains a leading cause of maternal morbidity and mortality in Sub-Saharan Africa. Prevention of mother-to-child transmission (PMTCT) has proven an effective strategy to end paediatric infections and ensure HIV-infected mothers access treatment. Based on cross-sectional data collected from June 2008 to May 2013, we assessed changes in HIV prevalence, risk factors for HIV, provision of PMTCT antiretroviral treatment (ART), and the association between HIV infection, birth outcomes and maternal characteristics at the Simão Mendes National Hospital, Guinea-Bissau’s largest maternity ward. Among 24,107 women, the HIV prevalence was 3.3% for HIV-1, 0.8% for HIV-2 and 0.9% for HIV-1/2. A significant decline in HIV-1, HIV-2, and HIV-1/2 prevalence was observed over time. HIV infection was associated with age and ethnicity. A total of 85% of HIV-infected women received ART as part of PMTCT, yet overall treatment coverage during labour and delivery declined significantly for both mothers and infants. Twenty-two percent of infants did not receive treatment, and 67% of HIV-2-infected mothers and 77% of their infants received ineffective non-nucleoside reverse transcriptase inhibitors for PMTCT. Maternal HIV was associated with low birth weight but not stillbirth. Inadequate continuity of care and ART coverage present challenges to optimal PMTCT in Guinea-Bissau. |
| Databáze: | OpenAIRE |
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