Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis
| Autor: | Joost B. L. Hoekstra, C. B. Brouwer, E. de Groot, J.J.P. Kastelein, Barbara A. Hutten, Frits Holleman, Hans Vink, Erik S.G. Stroes, M. J. Chapman, Anatol Kontush, Johan Gort, Max Nieuwdorp |
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| Přispěvatelé: | Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, Epidemiology and Data Science |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Endothelium Adolescent Endocrinology Diabetes and Metabolism Intima-media thickness Hyaluronidase Type 1 diabetes mellitus Hyaluronoglucosaminidase Diabetic angiopathy Article chemistry.chemical_compound Internal medicine Hyaluronic acid medicine Internal Medicine Humans Hyaluronic Acid Child Hyaluronan Aged Type 1 diabetes business.industry Vascular disease Middle Aged medicine.disease Tunica intima Atherosclerosis medicine.anatomical_structure Endocrinology Carotid Arteries Diabetes Mellitus Type 1 chemistry cardiovascular system business Tunica Intima Tunica Media Diabetic Angiopathies medicine.drug |
| Zdroj: | Diabetologia Diabetologia, 50(6), 1288-1293. Springer Verlag |
| ISSN: | 1432-0428 0012-186X |
| Popis: | AIMS/HYPOTHESIS: Cardiovascular disease contributes to mortality in type 1 diabetes mellitus, but the specific pathophysiological mechanisms remain to be established. We recently showed that the endothelial glycocalyx, a protective layer of proteoglycans covering the endothelium, is severely perturbed in type 1 diabetes, with concomitantly increased plasma levels of hyaluronan and hyaluronidase. In the present study, we evaluated the relationship between hyaluronan and hyaluronidase with carotid intima-media thickness (cIMT), an established surrogate marker for cardiovascular disease. SUBJECTS AND METHODS: Non-smoking type 1 diabetes patients without micro- or macrovascular complications and matched controls were recruited and cIMT of both carotid arteries was measured. To evaluate the relationship between cIMT and hyaluronan and hyaluronidase as well as other parameters, uni- or multivariate regression analyses were performed. RESULTS: We included 99 type 1 diabetes patients (age 10-72 years) and 99 age- and sex-matched controls. Mean cIMT, HbA(1c), high sensitivity C-reactive protein, hyaluronan and hyaluronidase were significantly increased in type 1 diabetes vs controls. Plasma hyaluronan and hyaluronidase were correlated in type 1 diabetes. In univariate regression analyses, mean IMT was associated with plasma hyaluronan, age and male sex, whereas after multivariate analysis only age and sex remained statistically significant. CONCLUSIONS/INTERPRETATION: We conclude that type 1 diabetes patients show structural changes of the arterial wall associated with increased hyaluronan metabolism. These data may lend further support to altered glycosaminoglycan metabolism in type 1 diabetes as a potential mechanism involved in accelerated atherogenesis |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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