Multicentric adult secretory breast carcinoma: DNA flow cytometric findings, prognostic features, and review of the world literature
| Autor: | Robert Marshall Austin, J. C. Hawk, A. S. Baker, Gene Richard |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Oncology
Adult medicine.medical_specialty medicine.medical_treatment Mammary gland Breast Neoplasms Modified Radical Mastectomy Internal medicine Cytology Medicine Neoplasm Humans Lymph node business.industry Carcinoma General Medicine DNA Neoplasm medicine.disease Flow Cytometry Prognosis Surgery Radiation therapy medicine.anatomical_structure Lymphatic Metastasis Adenocarcinoma Female business Secretory Breast Carcinoma Mammography |
| Zdroj: | Journal of surgical oncology. 44(4) |
| ISSN: | 0022-4790 |
| Popis: | A case of multicentric secretory breast carcinoma in a 39-year-old white female is described. Mammograms, DNA analysis, touch preparation cytology, and positive estrogen receptors are reported for the first time in this rare favorable mammary carcinoma. A review of the 33 reported cases with follow-up in adult females, including the present case, has revealed lymph node metastases in nine (27%), recurrence in four (12%), and distant metastases leading to death in two cases (6%). In patients treated with less than simple mastectomy there has been local recurrence in 4 (33%) of 12 cases and in three of the four cases (75%) greater than or equal to 2.0 cm. Increased size and lack of gross circumscription of the neoplasm and presentation in the adult age group appear to identify cases with an increased risk of disease progression. In patients over 20 years old, especially with neoplasms greater than 2 cm in diameter, modified radical mastectomy has to date achieved the most favorable outcome. Minimal experience (two cases) is available regarding treatment with limited surgery and radiation therapy, and there is no available data regarding possible benefit from adjuvant chemotherapy. |
| Databáze: | OpenAIRE |
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