A Diagnostic Test for Distinguishing Pemphigus, Dermatitis Herpetiformis, Disseminate Lupus Erythematosus and Erythema Multiforme Exudativum11Abridgement of Thesis submitted to the Faculty of the Graduate school of the University of Minnesota in Partial fulfillment of the requirements of the degree of M.S. in Dermatology and Syphilology

Autor: Ashton L. Welsh
Rok vydání: 1948
Předmět:
Zdroj: Journal of Investigative Dermatology. 11(1):19-48
ISSN: 0022-202X
DOI: 10.1038/jid.1948.64
Popis: The cataphoretic mobility-reducing action of the serums from patients with pemphigus, dermatitis herpetiformis, disseminate lupus erythematosus and erythema multiforme exudativum on the respective streptococci isolated from patients with each of these diseases, as shown by comparison with the mobility of these organisms in sodium chloride solution, was found to be so specific in experiments already recorded (1, 2, 3, 4) that an attempt was made to apply this action as a differential diagnostic test for these four diseases. The preliminary results of these studies have already been reported (5). This report deals with an analysis of the results of this test as applied to the serums of 322 patients.! TECHNIC Four antigens were used in this test. One consisted of a pool of strains of streptococci isolated from patients who had pemphigus, one consisted of a pool of strains isolated from patients who had dermatitis herpetiformis, one consisted of a pool of strains isolated from patients who had disseminate lupus erythematosus and another consisted of a pool of strains isolated from patients who had erythema multiforme exudativum. These streptococci were grown and stored as single strains in the manner already described for the handling of streptococci obtained from patients who had pemphigus, for the determination of cataphoretic mobility in immune serums (1). The strains which were to be included in the pool used as the pemphigus antigen and which were isolated from patients who had pemphigus were selected in the following manner. Each of these strains was tested individually against the serums obtained from each of five f It has been possible to obtain this number of serums and the information regarding the subsequent course of the patients from whom they were taken only through the kind cooperation of the following physicians: H. R. Amberson, N. P. Anderson, Samuel Ayres, Jr., R. D. Baker, S. W. Becker, M. D. Berger, George Brock, J. A. Borghoff, Earl Cilley, Arthur Cipollaro, Lester Cohen, Theodore Cornbleet, G. M. Crawford, C. C. Dennie, S. E. Dorst, H. R. Foerster, W. K. Ford, T. E. Fuller, A. J. Geiger, Arthur Greenwood, C. J. Gunn, Lester Hollander, W. R. Jaffrey, R. L. Kile, C. Guy Lane, C. W. Lane, C. F. Lehmann, G. M. MacKee, J. F. Madden, M. F. McCarthy, J. C. Michael, H. E. Michelson, J. H. Mitchell, E. P. Monahan, W. H. Mook, Joseph Muller, Ruben Nomland, F. C. Novy, Jr., M. E. Obermayer, O. S. Ormsby, Reuben Ottenberg, C. R. Rein, C. W. F. Rembert, C. L. Schmitt, H. J. Schwartz, F. E. Senear, T. P. Sharkey, W. S. Simpson, A. W. Stillians, Paul Stockey, M. J. Strauss, M. B. Sulzberger, S. W. Sweitzer, H. J. Templeton, J. V. VanCleve, M. S. Wein, R. S. Weiss, Udo J. Wile, Fred Wise, and K. G. Zwick.
Databáze: OpenAIRE
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