Assessment of symmetric dimethylarginine as a biomarker of renal function in hyperthyroid cats treated with radioiodine
| Autor: | Sylvie Daminet, Eva Vandermeulen, Hervé P. Lefebvre, Pascale Smets, Lisa Stammeleer, Emmelie Stock, Luc Duchateau, Dominique Paepe, Eva Buresova |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Symmetric dimethylarginine Population Urology Renal function Standard Article 131I Arginine Cat Diseases Kidney Function Tests Hyperthyroidism GFR Blood Urea Nitrogen Iodine Radioisotopes chemistry.chemical_compound Endocrinology CKD medicine Animals Prospective Studies Veterinary Sciences feline Prospective cohort study education glomerular filtration rate education.field_of_study Creatinine CATS symmetric dimethylarginine General Veterinary business.industry Standard Articles chemistry Cats Biomarker (medicine) Female SMALL ANIMAL business Biomarkers chronic kidney disease Glomerular hyperfiltration |
| Zdroj: | JOURNAL OF VETERINARY INTERNAL MEDICINE Journal of Veterinary Internal Medicine |
| ISSN: | 1939-1676 0891-6640 |
| Popis: | BACKGROUND: Measurement of serum creatinine (sCr) and urea nitrogen fail to detect decreased renal function in many hyperthyroid cats because of low muscle mass and glomerular hyperfiltration of affected cats. Serum symmetric dimethylarginine (sSDMA) is an earlier and more sensitive renal biomarker than sCr. OBJECTIVE: Evaluate sSDMA as a biomarker of renal function in hyperthyroid cats before (T0) and 1 month after (T1) radioiodine (¹³¹I) treatment. ANIMALS: Forty‐seven client‐owned hyperthyroid nonazotemic cats were evaluated at T0 and T1. METHODS: A prospective study in which sCr and sSDMA concentrations were determined in 47 hyperthyroid cats at T0 and at T1. Glomerular filtration rate (GFR) was estimated at T0 and T1 in 10 of these 47 cats using plasma exogenous creatinine clearance test. RESULTS: Serum SDMA was elevated (>14 μg/dL) in 6 of 47 cats at T0 and normalized after treatment in 4 of those cats. All cats remained nonazotemic after treatment. In 10 cats in which GFR was measured, correlation between GFR and sSDMA was low and not significant (τb = −0.35, P = .17 at T0 and τb = −.22, P = .41 at T1), whereas correlation between GFR and sCr was moderate and significant (τb = −0.52, P |
| Databáze: | OpenAIRE |
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