Personalized Approach to Determination of Histidine-Rich Glycoprotein and E-Cadherin in Supernatants of Immunocompetent Blood Cells and Breast Biopsy Specimens in Breast Malignant and Non-Malignant Disease
| Autor: | S V Sidorov, K I Davletova, S. A. Arkhipov, I.P. Zhurakovskiy, A V Proskura, A A Studenikina, A V Bernado, A I Autenshlyus, V V Lyakhovich, N A Varaksin |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Histidine-rich glycoprotein Biopsy Mammary gland Biophysics Breast Neoplasms Biochemistry CDH1 03 medical and health sciences Antigens CD Biomarkers Tumor medicine Humans Breast 030304 developmental biology chemistry.chemical_classification 0303 health sciences biology business.industry Cadherin Gene Expression Profiling 030302 biochemistry & molecular biology Proteins General Chemistry General Medicine Cadherins medicine.disease Immunohistochemistry Gene Expression Regulation Neoplastic medicine.anatomical_structure chemistry Invasive carcinoma of no special type Polyclonal antibodies biology.protein Female business Glycoprotein |
| Zdroj: | Doklady Biochemistry and Biophysics. 490:1-4 |
| ISSN: | 1608-3091 1607-6729 |
| DOI: | 10.1134/s1607672920010019 |
| Popis: | The material of patients with invasive carcinoma of no special type (ICNT) and nonmalignant diseases (ND) of the mammary gland was studied. When comparing the concentrations of histidine-rich glycoprotein (HRG) and E-cadherin (CDH1), statistically significant differences between ICNT and ND by HRG in the supernatant of blood cells and its spontaneous production by biopsies and by CDH1 at its induced production, as well as by influence indices of polyclonal activators on the production of CDH1 were found. When comparing the expression of immunohistochemical markers, no statistically significant differences between ICNT and ND were obtained. |
| Databáze: | OpenAIRE |
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