Antidiabetic Activity of Cactus Acid Fruit Extracts: Simulated Intestinal Conditions of the Inhibitory Effects on α-amylase and α-glucosidase
| Autor: | Ana Karen Zaldívar-Ortega, Gabriela Medina-Pérez, Rodolfo Vieyra-Alberto, José Antonio Estefes-Duarte, Rafael G. Campos-Montiel, Antonio de Jesús Cenobio-Galindo, Laura N. Afanador-Barajas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
xoconostle
030309 nutrition & dietetics Flavonoid phenols lcsh:Technology lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Phenol General Materials Science Amylase Phenols Gallic acid Food science Instrumentation lcsh:QH301-705.5 Gram Fluid Flow and Transfer Processes chemistry.chemical_classification 0303 health sciences biology lcsh:T Process Chemistry and Technology General Engineering food and beverages 04 agricultural and veterinary sciences 040401 food science lcsh:QC1-999 Computer Science Applications chemistry lcsh:Biology (General) lcsh:QD1-999 lcsh:TA1-2040 Cactus flavonoids diabetes mellitus biology.protein Quercetin lcsh:Engineering (General). Civil engineering (General) lcsh:Physics |
| Zdroj: | Applied Sciences, Vol 9, Iss 19, p 4066 (2019) Applied Sciences Volume 9 Issue 19 |
| ISSN: | 2076-3417 |
| Popis: | Acid cactus fruits &ldquo xoconostle&rdquo have been used since the pre-Columbian period as a treatment against diverse diseases. In this study, bioactive compounds (phenols and flavonoids) and the in vitro inhibition effect against &alpha amylase and &alpha glucosidase were evaluated. Four different extracts of cactus acid fruits were prepared from (1) endocarp, (2) mesocarp, (3) pericarp and (4) whole fruit (WFE). The results showed significant differences (p < 0.05) between extracts. Pericarp extracts had 2.23 ± 0.01 mg of gallic acid equivalents per gram GAE/g of phenol content and 0.84 ± 0.14 mg quercetin equivalents per gram QE/g flavonoid content, while WFE presented 1.52 ± 0.04 mg GAE/g and 0.84 ± 0.14 mg QE/g however, the inhibition of &alpha glucosidase were higher with WFE. It was found by using 25 mg/mL of WFE an &alpha amylase inhibition of 63. ± 1.53% and with 30 mg/mL of WFE an &alpha glucosidase inhibition of 46.5 ± 1.45% after simulated intestinal conditions. The WFE could be used as a therapeutic strategy in controlled diets of diabetic patients due to its low cost, natural origin, and effect after simulated intestinal conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|