Optimization of Vortex-Assisted Dispersive Liquid-Liquid Microextraction for the Simultaneous Quantitation of Eleven Non-Anthocyanin Polyphenols in Commercial Blueberry Using the Multi-Objective Response Surface Methodology and Desirability Function Approach

Autor: Li Yong, Lin-Sen Qing, Yi Li, Bin Hu, Ying Xue, Xing-De Li, Shi-Hong Zhong, Xian-Shun Xu, Jing Xie
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Liquid Phase Microextraction
Blueberry Plants
Ethyl acetate
Pharmaceutical Science
Epigallocatechin gallate
01 natural sciences
Article
Analytical Chemistry
Ferulic acid
lcsh:QD241-441
response surface methodology
chemistry.chemical_compound
lcsh:Organic chemistry
Limit of Detection
Drug Discovery
Vanillic acid
Gallocatechin gallate
Gallic acid
Physical and Theoretical Chemistry
Chromatography
High Pressure Liquid
blueberry
Analysis of Variance
Chromatography
010405 organic chemistry
010401 analytical chemistry
Organic Chemistry
Polyphenols
Syringic acid
0104 chemical sciences
vortex-assisted dispersive liquid-liquid microextraction
chemistry
non-anthocyanin polyphenol
Chemistry (miscellaneous)
Polyphenol
Spectrometry
Mass
Matrix-Assisted Laser Desorption-Ionization
Molecular Medicine
desirability function approach
Zdroj: Molecules
Volume 23
Issue 11
Molecules, Vol 23, Iss 11, p 2921 (2018)
ISSN: 1420-3049
Popis: In the present study, 11 non-anthocyanin polyphenols, gallic acid, protocatechuate, vanillic acid, syringic acid, ferulic acid, quercetin, catechin, epicatechin, epigallocatechin gallate, gallocatechin gallate and epicatechin gallate&mdash
were firstly screened and identified from blueberries using an ultra performance liquid chromatography&ndash
time of flight mass spectrography (UPLC-TOF/MS) method. Then, a sample preparation method was developed based on vortex-assisted dispersive liquid-liquid microextraction. The microextraction conditions, including the amount of ethyl acetate, the amount of acetonitrile and the solution pH, were optimized through the multi-objective response surface methodology and desirability function approach. Finally, an ultra performance liquid chromatography&ndash
triple quadrupole mass spectrography (UPLC-QqQ/MS) method was developed to determine the 11 non-anthocyanin polyphenols in 25 commercial blueberry samples from Sichuan province and Chongqing city. The results show that this new method with high accuracy, good precision and simple operation characteristics, can be used to determine non-anthocyanin polyphenols in blueberries and is expected to be used in the analysis of other fruits and vegetables.
Databáze: OpenAIRE
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