Successfully treated bronchopulmonary oxalosis caused by Aspergillus tubingensis in a non-neutropenic patient: A case report and review of the literature
| Autor: | Hirohisa Horinouchi, Hiroki Tateno, Kei Sakamoto, Isano Hase, Jin Kagatani, Fumio Maitani, Katsuhiko Kamei, Shuichi Yoshida, Shoji Suzuki |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
Voriconazole Hyperoxaluria medicine.medical_specialty Aspergillus Antifungal Agents biology business.industry Mortality rate Microbial Sensitivity Tests Disease Drug susceptibility Necrotic tissue biology.organism_classification Gastroenterology Non neutropenic Infectious Diseases Aspergillus tubingensis Internal medicine medicine Humans Pharmacology (medical) business medicine.drug |
| Zdroj: | Journal of Infection and Chemotherapy. 28:299-303 |
| ISSN: | 1341-321X |
| Popis: | Pulmonary oxalosis can be fatal, and Aspergillus tubingensis is commonly resistant to azoles in Japan. We report a case of bronchopulmonary oxalosis caused by A. tubingensis in a non-neutropenic patient who was successfully treated with voriconazole monotherapy. The susceptibility of the isolates to voriconazole and the effective elimination of contagious necrotic tissue by expectoration seemed to be two major factors contributing to the patient's survival. According to the literature review, pulmonary oxalosis is associated with a high mortality rate over a short term. An exploration of detailed information about the genomic characteristics and drug susceptibility of Aspergillus isolates is important for the development of treatment strategies for this life-threatening disease. |
| Databáze: | OpenAIRE |
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