IL-2 increased RANTES production and CD25 expression in cultured PBMCs only from antiretroviral treated HIV-1+ patients with detectable viral loads
| Autor: | José María Kindelán, Almudena Cabello, José Peña, José Manuel Lozano, Rafael Solana, Rafael González |
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| Rok vydání: | 2006 |
| Předmět: |
CD4-Positive T-Lymphocytes
Interleukin 2 Chemokine medicine.medical_treatment Immunology HIV Infections Biology Peripheral blood mononuclear cell Virus Antigens CD Antiretroviral Therapy Highly Active medicine Humans Immunology and Allergy Chemokine CCL5 Cells Cultured Pharmacology Receptors Interleukin-2 hemic and immune systems Viral Load biology.organism_classification Virology CD4 Lymphocyte Count Cytokine Lentivirus HIV-1 Leukocytes Mononuclear biology.protein Interleukin-2 RNA Viral Viral disease Viral load medicine.drug |
| Zdroj: | International Immunopharmacology. 6:1034-1038 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2006.01.002 |
| Popis: | In order to better understand the possible beneficial effects of intermittent IL-2 treatment as complement of antiretroviral therapy in HIV-1+ patients, we have measured the levels of RANTES in the supernatants and the CD25 expression in cultured PBMCs obtained from HIV-1+ individuals in presence of IL-2. The results showed a significant increases in RANTES production and in the expression of CD25+ in the cultures with IL-2 of PBMC obtained from HIV-1+ patients with a detectable viral load in comparison with both, HIV-1+ patients with no detectable viral loads and with healthy individuals. These results suggest that therapeutic IL-2 administered in addition to highly active anti-retroviral therapy (HAART) may contribute to increase the effect of this therapy by rising both RANTES production and CD25 expression only in HIV-1+ patients with detectable viral loads. |
| Databáze: | OpenAIRE |
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