Frontal and superior temporal auditory processing abnormalities in schizophrenia
| Autor: | Emerson M. Epstein, Breannan C. Howell, Michael A. Hunter, Juan R. Bustillo, J. Christopher Edgar, Gregory A. Miller, Yu-Han Chen, Brett Y. Lu, Mingxiong Huang, José M. Cañive |
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| Rok vydání: | 2013 |
| Předmět: |
SFG
superior frontal gyrus genetic structures SMG supramarginal gyrus ERP event-related potential Electroencephalography S1 first click Superior temporal gyrus PFC prefrontal cortex 0302 clinical medicine Cortex (anatomy) VESTAL Vector-based Spatio-temporal Analysis using L1-minimum norm IFG inferior frontal gyrus HC healthy controls STG superior temporal gyrus Auditory SSS Signal Space Separation MEG medicine.diagnostic_test ERF event-related field SMA supplementary motor area 05 social sciences SES socioeconomic status EOG electro-oculogram FDR false discovery rates medicine.anatomical_structure Neurology fMRI functional magnetic resonance imaging Schizophrenia Psychology ITG inferior temporal gyrus EEG electroencephalography Cognitive Neuroscience Inferior frontal gyrus behavioral disciplines and activities Article Frontal cortex 050105 experimental psychology 03 medical and health sciences Group differences medicine 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging PANSS Positive and Negative Syndrome Scale S2 second click sMRI structural magnetic resonance imaging Magnetoencephalography MEG magnetoencephalography medicine.disease SSS ECG electrocardiogram DTI diffusion tensor imaging Neurology (clinical) Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2013.05.002 |
| Popis: | Background Although magnetoencephalography (MEG) studies show superior temporal gyrus (STG) auditory processing abnormalities in schizophrenia at 50 and 100 ms, EEG and corticography studies suggest involvement of additional brain areas (e.g., frontal areas) during this interval. Study goals were to identify 30 to 130 ms auditory encoding processes in schizophrenia (SZ) and healthy controls (HC) and group differences throughout the cortex. Methods The standard paired-click task was administered to 19 SZ and 21 HC subjects during MEG recording. Vector-based Spatial–temporal Analysis using L1-minimum-norm (VESTAL) provided 4D maps of activity from 30 to 130 ms. Within-group t-tests compared post-stimulus 50 ms and 100 ms activity to baseline. Between-group t-tests examined 50 and 100 ms group differences. Results Bilateral 50 and 100 ms STG activity was observed in both groups. HC had stronger bilateral 50 and 100 ms STG activity than SZ. In addition to the STG group difference, non-STG activity was also observed in both groups. For example, whereas HC had stronger left and right inferior frontal gyrus activity than SZ, SZ had stronger right superior frontal gyrus and left supramarginal gyrus activity than HC. Conclusions Less STG activity was observed in SZ than HC, indicating encoding problems in SZ. Yet auditory encoding abnormalities are not specific to STG, as group differences were observed in frontal and SMG areas. Thus, present findings indicate that individuals with SZ show abnormalities in multiple nodes of a concurrently activated auditory network. Highlights • Auditory encoding in schizophrenia (SZ) and healthy controls (HC) was examined. • Distributed source localization provided whole-brain measures from 30 to 130 ms. • Abnormalities were observed in superior temporal gyrus (STG) auditory areas in SZ. • Encoding abnormalities were also observed in frontal and supramarginal gyrus areas. • SZ shows abnormalities in multiple nodes of a distributed auditory network. |
| Databáze: | OpenAIRE |
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