Limbs and trunk soft tissue sarcoma systematic local and remote monitoring by MRI and thoraco-abdomino-pelvic scanner: A single-centre retrospective study
| Autor: | Floriane De Angelis, France Guy, Aurélie Bertaut, Nathalie Méjean, Olivier Varbedian, Alice Hervieu, Gilles Truc, David Thibouw, Céline Charon Barra, Jean Fraisse, Pierre Burnier, Nicolas Isambert, Sylvain Causeret |
|---|---|
| Přispěvatelé: | Service de radiologie [Centre Georges-François Leclerc], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Unité de Méthodologie, Biostatistiques et Data Management [Centre Georges François Leclerc], Département d'oncologie médicale [Centre Georges-François Leclerc], Service de radiothérapie [Centre Georges-François Leclerc], UNICANCER, Service de chirurgie [Centre Georges-François Leclerc] |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms [SDV]Life Sciences [q-bio] Aftercare Bone Neoplasms Soft Tissue Neoplasms Kaplan-Meier Estimate Pelvis Young Adult 03 medical and health sciences Tumor grade 0302 clinical medicine Abdomen medicine Humans Neoplasm Metastasis Peritoneal Neoplasms Aged Proportional Hazards Models Retrospective Studies Aged 80 and over 030222 orthopedics business.industry Soft tissue sarcoma Torso Soft tissue Extremities Sarcoma Retrospective cohort study General Medicine Middle Aged Thorax medicine.disease Magnetic Resonance Imaging Trunk 3. Good health Single centre Oncology 030220 oncology & carcinogenesis Monitoring data Radiological weapon Female Surgery Radiology Neoplasm Recurrence Local Tomography X-Ray Computed business |
| Zdroj: | EJSO-European Journal of Surgical Oncology EJSO-European Journal of Surgical Oncology, WB Saunders, 2019, 45, pp.1274-1280. ⟨10.1016/j.ejso.2019.02.002⟩ |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2019.02.002 |
| Popis: | Introduction Soft tissue sarcomas (STS) are rare malignant tumors that require management by an expert center. Monitoring modalities are not consensual. The objective of our study is to report systematic radiological monitoring data obtained by local MRI and by thoracic-abdominal-pelvic computed tomography (TAP CT). Material and methods 113 consecutive patients managed at “Centre Georges Francois Leclerc, Dijon”, between 2008 and 2016, for an initially localized STS were included. Patient follow-up consisted of a local MRI and a TAP CT. Follow-up exams schedule was initially every 4 months during 2 years, followed by every 6 months during 3 years and finally every year during 5 years. Results Median follow-up time was 37.2 months [min = 2.4 – max = 111.6]. After 5 years of surveillance, local recurrence (LR) rate was 8.8% and diagnosed by imaging in 60% of cases. No deep LR was clinically found. Median LR diagnosis time was 23.9 months [min = 2.0 – max = 52.4]. 50% of patients locally treated for their LR were alive without recurrence. Metastatic recurrence (MR) rate was 31%. 42.8% had extra-pulmonary involvement and 17.1% had exclusive extrathoracic metastases. The median time to diagnosis of MR was 17.4 months [min = 2.7- max = 77.2]. High-grade tumors relapsed more (20.4%) and earlier (all before the 5th year) than low grade. Conclusion Local MRI seems particularly suitable for monitoring deep tumors. In addition, the systematic monitoring by TAP CT highlighted a limited number of cases of exclusive extrathoracic metastases. The schedule of local and remote monitoring should primarily be adjusted to tumor grade. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect