Relieving immunosuppression by Endo@PLT targeting anti-angiogenesis to improve the efficacy of immunotherapies
| Autor: | Chao, Chen, Yijie, Tang, Hao, Huang, Li, Jia, Lingzi, Feng, Jianya, Zhao, Hao, Zhang, Jian, He, Lingchi, Ding, Donglin, Xia |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Immunosuppression Therapy
Neovascularization Pathologic Metals and Alloys Angiogenesis Inhibitors Neoplasms Experimental General Chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Mice Inbred C57BL Mice Neoplasms Tumor Microenvironment Materials Chemistry Ceramics and Composites Animals Humans Immunotherapy |
| Zdroj: | Chemical Communications. 58:3202-3205 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | Low levels of immune infiltrates in the tumor milieu hinder the effectiveness of immunotherapy against immune-cold tumors. In the current work, a tumor-targeting drug delivery system composed of Endo-loaded platelets (Endo@PLT) was developed to relieve immunosuppression by achieving tumor vascular normalization. Endo@PLT reprogrammed the immunostimulatory phenotype, achieving excellent PD-1 immunotherapy |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|