Identification of characteristic IGF2BP expression patterns in distinct B-ALL entities
| Autor: | Regina Pileckyte, Mindaugas Stoškus, Vilma Valceckiene, Beatrice Valatkaite, Egle Gineikiene, Laimonas Griskevicius |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_treatment
Biology Severity of Illness Index Recurrence hemic and lymphatic diseases Precursor B-Cell Lymphoblastic Leukemia-Lymphoma medicine Biomarkers Tumor Neoplasm Humans RNA Neoplasm Molecular Biology Regulation of gene expression Proto-Oncogene Proteins c-ets Gene Expression Regulation Leukemic Growth factor breakpoint cluster region RNA-Binding Proteins Cell Biology Hematology medicine.disease Prognosis Repressor Proteins Leukemia ETV6 Haematopoiesis medicine.anatomical_structure Core Binding Factor Alpha 2 Subunit Cancer research Molecular Medicine Bone marrow |
| Zdroj: | Blood cells, moleculesdiseases. 46(4) |
| ISSN: | 1096-0961 |
| Popis: | Insulin-like growth factor 2 mRNA-binding proteins IGF2BP1, IGF2BP2, and IGF2BP3 have been shown to have diagnostic and prognostic utility in a number of epithelial and soft tissue tumors. Still, little is known about the expression of these molecules in different types of leukemia and our study aims to fill this gap. By using an RT-qPCR approach, we have systemically analyzed the expression of three IGF2BP coding genes in normal hematopoietic tissues and distinct acute lymphoblastic leukemia (ALL) entities. We show that low/negative IGF2BP1 and IGF2BP3 and high IGF2BP2 levels are characteristic to healthy donor bone marrow and peripheral blood whereas different B-ALL entities displayed characteristic perturbations of IGF2BP expression patterns. Namely, we have identified significant associations of overexpressed IGF2BP1 with ETV6/RUNX1-positive (r(2)=0.7891, y=0.8105x-0.4471, p |
| Databáze: | OpenAIRE |
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