Experimental Colonic Inflammation and Ulceration: Permeation of a Water-Soluble Contrast Medium as a Measure of ‘Disease’ Activity
| Autor: | R. Andersen, D. Bay, K. Aas, A. Stordahl, T. S. Halstensen, F. Lærum |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Pathology Colon medicine.medical_treatment Contrast Media Inflammation Urine Gastroenterology Permeability Excretion Triiodobenzoic Acids Internal medicine medicine Animals Intestinal Mucosa Saline Ulcer business.industry Enema Colitis Anus Iodixanol Rats Radiography Contrast medium medicine.anatomical_structure Solubility medicine.symptom business medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 27:757-763 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365529209011179 |
| Popis: | The aim of this study was to investigate the permeation of an isosmolar water-soluble X-ray contrast medium (CM) from the unperforated colon after experimental induction of inflammation and ulceration. One hundred and sixty-five male rats were included. In 110 rats 0.25 ml of 40% ethanol + 15 mg or 30 mg trinitrobenzene (TNB) was instilled into the colon, 7-9 cm proximal to the anus, inducing different degrees of inflammation. Fifty-five rats served as controls and had 0.25 ml saline instilled with the same procedure. At 7, 14, 21, and 28 days 3 ml of the non-ionic CM iodixanol was applied as an enema, and subsequently all urine was collected for the next 4 h. High-performance liquid chromatography analyses of the urine showed a positive relation between the severity of inflammation/ulceration in the colonic wall as assessed by a macroscopic damage score and the amount of CM excreted in the urine. Water-soluble contrast media may have prospects of combining functional tests of intestinal membrane dysfunction with segmental exposure control. |
| Databáze: | OpenAIRE |
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