Impact of functional inorganic nanotubes f-INTs-WS2 on hemolysis, platelet function and coagulation
| Autor: | Jean-Michel Dogné, Hélène Haguet, Daniel Raichman, Jean-Paul Lellouche, Lütfiye Alpan, Julie Laloy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Thrombin generation
lcsh:Biotechnology Tungsten disulfide 02 engineering and technology engineering.material 010402 general chemistry lcsh:Chemical technology 01 natural sciences lcsh:Technology Hemocompatibility Nanomaterials chemistry.chemical_compound Coating lcsh:TP248.13-248.65 medicine Coagulation (water treatment) Molecule General Materials Science Platelet Reactivity (chemistry) lcsh:TP1-1185 lcsh:Science lcsh:T Research General Engineering 021001 nanoscience & nanotechnology medicine.disease Functional tungsten disulfide nanotubes Hemolysis lcsh:QC1-999 0104 chemical sciences chemistry engineering Biophysics lcsh:Q Safety 0210 nano-technology lcsh:Physics |
| Zdroj: | Nano Convergence Nano Convergence, Vol 5, Iss 1, Pp 1-10 (2018) Laloy, J, Haguet, H, Alpan, L, Raichman, D, Dogné, J-M & Lellouche, J-P 2018, ' Impact of functional inorganic nanotubes f-INTs-WS2 on hemolysis, platelet function and coagulation ', Nano convergence, vol. 5, no. 1, 31 . https://doi.org/10.1186/s40580-018-0162-1 |
| ISSN: | 2196-5404 |
| DOI: | 10.1186/s40580-018-0162-1 |
| Popis: | Inorganic transition metal dichalcogenide nanostructures are interesting for several biomedical applications such as coating for medical devices (e.g. endodontic files, catheter stents) and reinforcement of scaffolds for tissue engineering. However, their impact on human blood is unknown. A unique nanomaterial surface-engineering chemical methodology was used to fabricate functional polyacidic polyCOOH inorganic nanotubes of tungsten disulfide towards covalent binding of any desired molecule/organic species via chemical activation/reactivity of this former polyCOOH shell. The impact of these nanotubes on hemolysis, platelet aggregation and blood coagulation has been assessed using spectrophotometric measurement, light transmission aggregometry and thrombin generation assays. The functionalized nanotubes do not induce hemolysis but decrease platelet aggregation and induce coagulation through intrinsic pathway activation. The functional nanotubes were found to be more thrombogenic than the non-functional ones, suggesting lower hemocompatibility and increased thrombotic risk with functionalized tungsten disulfide nanotubes. These functionalized nanotubes should be used with caution in blood-contacting devices. |
| Databáze: | OpenAIRE |
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