Microneedles for Extended Transdermal Therapeutics: A Route to Advanced Healthcare
| Autor: | Vivek M. Ghate, Suman Pahal, Utkarsh Bhutani, Dinesh Narasimhaiah Subramanyam, Mangalore Manjunatha Nayak, Kedar Badnikar, Praveen Kumar Vemula |
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| Rok vydání: | 2020 |
| Předmět: |
Polymers
Drug Compounding Drug Evaluation Preclinical Pharmaceutical Science Transdermal Patch Nanotechnology 02 engineering and technology Administration Cutaneous 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Therapeutic index Medicine Animals Humans Transdermal Skin Clinical Trials as Topic Drug Carriers business.industry Polymeric matrix General Medicine 021001 nanoscience & nanotechnology Drug Liberation Solubility Needles Delayed-Action Preparations Drug delivery Models Animal 0210 nano-technology business Biotechnology |
| Zdroj: | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 159 |
| ISSN: | 1873-3441 |
| Popis: | Sustained release of drugs over a pre-determined period is required to maintain an effective therapeutic dose for variety of drug delivery applications. Transdermal devices such as polymeric microneedle patches and other microneedle-based devices have been utilized for sustained release of their payload. Swift clearing of drugs can be prevented either by designing a slow-degrading polymeric matrix or by providing physiochemical triggers to different microneedle-based devices for on-demand release. These long-acting transdermal devices prevent the burst release of drugs. This review highlights the recent advances of microneedle-based devices for sustained release of vaccines, hormones, and antiretrovirals with their prospective safe clinical translation. |
| Databáze: | OpenAIRE |
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