Onset of peripheral arterial disease: role of endothelin in endothelial dysfunction
| Autor: | Aurora Florez Gonzalez, Cesar Varela Casariego, Francisco Acín García, Joaquín de Haro Miralles |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.hormone Male medicine.medical_specialty Time Factors Ischemia Inflammation Gastroenterology Risk Assessment Severity of Illness Index Endothelins Internal medicine medicine Humans Endothelial dysfunction Aged Peripheral Vascular Diseases biology business.industry C-reactive protein Intermittent Claudication Middle Aged medicine.disease Intermittent claudication Cross-Sectional Studies biology.protein Disease Progression Surgery Female Endothelium Vascular medicine.symptom Cardiology and Cardiovascular Medicine Claudication business Endothelin receptor Biomarkers Follow-Up Studies |
| Zdroj: | Interactive cardiovascular and thoracic surgery. 10(5) |
| ISSN: | 1569-9285 |
| Popis: | OBJECTIVES Endothelial dysfunction and inflammation are understood to contribute to the onset of peripheral arterial disease (PAD), and endothelin (ET) may play an important role in this process. This study investigated the role of ET in PAD, and its relationships with symptoms, endothelial dysfunction and inflammation. METHODS AND RESULTS This cross-sectional study enrolled 141 participants: 66 patients with PAD and intermittent claudication, 37 patients with PAD and critical ischemia, and 38 healthy controls aged under 35 years. There were no gender distribution differences between control and diseased groups. Moreover, no differences were observed in age or cardiovascular risk factors distribution between patients with critical ischemia and patients with claudication. Plasma ET concentrations were significantly higher in patients vs. controls (8.76+/-77.1 vs. 6.45+/-0.89 pmol/l, respectively; P=0.002). Nevertheless, patients with claudication exhibited significantly higher plasma ET concentrations vs. patients with critical ischemia (10.97+/-7.9 vs. 4.82+/-2.57 pmol/l, respectively; P |
| Databáze: | OpenAIRE |
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