The effect of heliox treatment in a rat model of focal transient cerebral ischemia
| Autor: | Salvador Cruz-Flores, W. Michael Panneton, Aninda B. Acharya, Yi Pan, Haibo Zhang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Time Factors Nitrogen Ischemia chemistry.chemical_element Helium Heliox Oxygen Rats Sprague-Dawley Brain ischemia Central nervous system disease Occlusion Animals Medicine Stroke business.industry Vascular disease General Neuroscience Oxygen Inhalation Therapy Infarction Middle Cerebral Artery medicine.disease Rats Disease Models Animal chemistry Ischemic Attack Transient Anesthesia Acute Disease business |
| Zdroj: | Neuroscience Letters. 497:144-147 |
| ISSN: | 0304-3940 |
| Popis: | Manipulation of inhaled gases during ischemia/reperfusion is a potential novel therapy for acute stroke. We previously found that treatment with a mixture of 70%/30% helium/oxygen (heliox) or 100% oxygen protects the brain against acute focal ischemia-reperfusion injury. This study evaluates the potential neuro-protective effects of delayed heliox treatment and its dose response effects in a rat transient focal cerebral ischemia model. Adult male rats were subjected to 2-h middle cerebral artery occlusion and then assigned to 1 of 4 inhaled gas exposure groups: I: 70%/30% nitrogen/oxygen (control); II: 70%/30% helium/oxygen administered immediately after occlusion; III: 70%/30% helium/oxygen administered after a 30-60 min delay; or, IV: 40%/30%/30% nitrogen/helium/oxygen administered immediately after occlusion. Outcome measurements included infarct size and neurological deficit score. Mean infarct sizes from groups I to IV were 228, 35, 109, and 124 mm³ respectively (p=0.012). Only group II had significantly smaller infarct size compared to the control group (p=0.008). In addition, only Group II had a significantly lower neurological deficit score at 24h post ischemia when compared to the control group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect