Age-related changes in pharmacokinetics and pharmacodynamics of lerisetron in the rat: a population pharmacokinetic model
| Autor: | Ewa Raczka, Leire de la Fuente, Elena Suarez, Antonio Quintana, Rosario Calvo, Nerea Jauregizar |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Aging Lerisetron medicine.drug_class Population Pharmacology Models Biological 5-HT3 Receptor Antagonist Pharmacokinetics Piperidines Age related Internal medicine medicine Animals Tissue Distribution education education.field_of_study business.industry Osmolar Concentration Bayes Theorem Receptor antagonist Rats Inbred F344 Rats Endocrinology Benzimidazoles Female Serotonin Geriatrics and Gerontology business medicine.drug Half-Life |
| Zdroj: | Gerontology. 49(4) |
| ISSN: | 0304-324X |
| Popis: | Background: The importance of studying the effects of age on the pharmacokinetics and pharmacodynamics of lerisetron – a new 5-hydroxytryptamine-3 (serotonin) receptor antagonist – comes from the facts that lerisetron will be administered to patients that are being treated with cytotoxic drugs and that the elderly frequently suffer from neoplastic diseases. Objective: The present study was designed to explore the effects of age on the pharmacokinetics and pharmacodynamics of lerisetron by using an aged rat model. A mixed-effects population study was carried out in order to analyze the sparse data and to create covariate models which could be used to derive dosage recommendations. Methods: Fischer 344 rats (n = 44) were divided into three groups, depending on their age: 5, 13, and 25 months. Blood samples were collected before administration of 200 µg/kg of lerisetron for measurements of albumin, α1-acid glycoprotein, and unbound fraction of lerisetron. The lerisetron plasma concentrations were measured by high-performance liquid chromatography. A two-compartment model was fitted to the data using the nonlinear mixed-effects computer program WinNonMix. The population analysis was performed with the complete set of the collected data, and the potential sources of variability in the population parameters were investigated. Additionally, a pharmacodynamic study was performed. The effect of lerisetron (inhibition of the von Bezold-Jarisch reflex) was evaluated in young, adult, and senescent Fischer 344 rats. Results: The mean values of the individual Bayes estimates of the parameters showed a decrease in total clearance and distribution volume of the central compartment in old rats. The lerisetron free (unbound) fraction remained unchanged among the groups, and there were no significant differences in α1-acid glycoprotein levels. The concentration-effect relationship was best described by a sigmoid Emax model. Since the drug concentration in plasma at half-maximal effect (EC50) decreased in old rats, an increased sensitivity to the effect of lerisetron in old animals could be expected. Conclusion: Both pharmacokinetic changes (decreased volume of distribution and clearance and increased elimination half-life) and pharmacodynamic alterations (decrease in total and unbound EC50) may be responsible for the different responses to lerisetron observed in old rats. |
| Databáze: | OpenAIRE |
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