A synthetic pathogen mimetic molecule induces a highly amplified synergistic immune response via activation of multiple signaling pathways†
| Autor: | Bradley Studnitzer, Naorem Nihesh, Saikat Manna, Jingjing Shen, Aaron P. Esser-Kahn |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Endosome Chemistry animal diseases chemical and pharmacologic phenomena General Chemistry biochemical phenomena metabolism and nutrition Cell biology 03 medical and health sciences Cytosol 0302 clinical medicine Immune system Molecule bacteria Signal transduction Receptor Pathogen 030304 developmental biology 030215 immunology |
| Zdroj: | Chemical Science |
| ISSN: | 2041-6539 2041-6520 |
| Popis: | The current understanding of how the immune system processes complex information during natural infections is yet to be exploited for the molecular design of potent immune activators. Here, we address this challenge by design of a pathogen-mimetic molecule that simultaneously co-activates cell-surface active, endosomal and cytosolic immune receptors. Different pathogen components were formulated as a single pathogen mimetic molecule. This combinatorial approach enables us to develop a potent vaccine adjuvant. |
| Databáze: | OpenAIRE |
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