The protective effect of Montelukast against skeletal muscle ischemia reperfusion injury: An experimental rat model
| Autor: | Mehmet İlker Bilgiç, Husamettin Cakici, Güray Altun, Kaan Gideroğlu, Gürsel Saka |
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| Rok vydání: | 2018 |
| Předmět: |
Cyclopropanes
Male medicine.medical_specialty Urology Ischemia Femoral artery Acetates Sulfides Protective Agents 03 medical and health sciences Random Allocation 0302 clinical medicine Edema medicine.artery Malondialdehyde Medicine Animals Rats Wistar Muscle Skeletal Montelukast Leukotriene business.industry Skeletal muscle medicine.disease Extravasation respiratory tract diseases Rats Anesthesiology and Pain Medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Reperfusion Injury Emergency Medicine Quinolines Surgery medicine.symptom business Reperfusion injury 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Ulusal travma ve acil cerrahi dergisi = Turkish journal of traumaemergency surgery : TJTES. 24(3) |
| ISSN: | 1306-696X |
| Popis: | BACKGROUND Montelukast is a selective leukotriene D-4 receptor antagonist, which specifically and reversibly inhibits cysteinyl leukotriene-1 receptor. The aim of this study was to investigate the protective effect of Montelukast on skeletal muscle reperfusion injury created as acute ischemia-reperfusion (IR) injury in Wistar-albino rats. METHODS The study comprised 16 male Wistar-albino rats. The rats were randomly separated into two groups as control (IR) and treatment (IR+Montelukast). Ischemia was obtained using a femoral artery clamp. After reperfusion following a 2-hour ischemia, muscle samples were taken for biochemical and histopathological analyses. RESULTS Malondialdehyde levels were determined to be at statistically higher levels in the control compared with that in the Montelukast group (p=0.002, p |
| Databáze: | OpenAIRE |
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