Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague–Dawley rats
| Autor: | Mary E. Hartnett Locke, Ian C. Lamb, Joel L. Mattsson, Raymond Layton, Jean Schmidt, Lora Deege, Bryan Delaney, Michael J. Morrisey, Lee M. Prochaska, Marc S. Harper, Craig D. Sanders, Susan A. MacKenzie, Angel M. Fuentes |
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| Rok vydání: | 2007 |
| Předmět: |
Male
European corn borer Bacterial Toxins Motor Activity Toxicology Zea mays Ostrinia Rats Sprague-Dawley Eating Hemolysin Proteins Animal science Bacterial Proteins Crambidae Bacillus thuringiensis Animals Poaceae Pyralidae Genetically modified maize Bacillus thuringiensis Toxins biology Body Weight food and beverages Organ Size General Medicine Alkaline Phosphatase Plants Genetically Modified biology.organism_classification Rats Genetically modified organism Endotoxins Agronomy Female Food Science |
| Zdroj: | Food and Chemical Toxicology. 45:551-562 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2006.09.016 |
| Popis: | Maize line 1507, containing event DAS-Ø15Ø7-1 (1507), is a genetically modified (GM) maize plant that expresses the cry1F gene from Bacillus thuringiensis (Bt) sbsp. aizawai and the phosphinothricin-N-acetyltransferase (pat) gene from Streptomyces viridochromogenes throughout the plant including in the grain expression of the Cry1F protein confers in planta resistance to the European corn borer (ECB; Ostrinia nubilalis Hübner: Crambidae) and other lepidopteran pests. Expression of the PAT protein confers tolerance to the herbicidal active ingredient glufosinate-ammonium. The current study evaluated the nutritional performance of rats fed diets containing 1507 maize grain in a subchronic rodent feeding study. The grains in this study, 1507, its near-isogenic control (33P66), and a non-GM commercial hybrid (33J56) contained similar amounts of proximates, amino acids, minerals, anti-nutrients, and secondary metabolites. The subchronic feeding study compared standard toxicology response variables in rats fed diets containing 1507 maize grain with those in rats fed diets containing non-GM maize grains. All diets were prepared according to the specifications of PMI Nutrition International, LLC Certified Rodent LabDiet 5002 (PMI) 5002). Diets were fed ad libitum to Sprague-Dawley rats for approximately 90 days. In-life response variables included indicators of dietary performance and weekly evaluations for clinical signs of toxicity. No toxicologically significant differences were observed in the nutritional performance variables, clinical and neurobehavioral signs, ophthalmology, clinical pathology (hematology, clinical chemistry, coagulation, and urinalysis), organ weights, and gross and microscopic pathology between any pair of treatment groups. These results demonstrate that 1507 maize grain is as safe and as nutritious as non-GM maize grain. |
| Databáze: | OpenAIRE |
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