SYNTHESIS OF NEW 6-[4-(2-FLUOROPHENYLPIPERAZINE-1-YL)]-3(2H)-PYRIDAZINONE-2-ACETHYL-2-(SUBSTITUTEDBENZAL)HYDRAZONE DERIVATIVES AND EVULATION OF THEIR CYTOTOXIC EFFECTS IN LIVER AND COLON CANCER CELL LINES

Autor:	Mehtap Uysal, Zeynep Özdemir, Nese Basak-Turkmen, İdris Ayhan, Osman Ciftci
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	antiproliferative activity MTS assay Colorectal cancer melting point Hydrazone 6 [4 (2 fluorophenyl)piperazine 1 yl] 3 (2h) pyridazinone 2 acetyl 2 (4 chlorobenzal)hydrazone IC50 6 [4 (2 fluorophenyl)piperazine 1 yl] 3 (2h) pyridazinone 2 acetyl 2 (2 chlorobenzal)hydrazone proton nuclear magnetic resonance Article fibroblast liver cancer 6 [4 (2 fluorophenyl)piperazine 1 yl] 3 (2h) pyridazinone 2 acetyl 2 benzalhydrazone Drug Discovery medicine Cytotoxic T cell human 6 [4 (2 fluorophenyl)piperazine 1 yl] 3 (2h) pyridazinone 2 acetyl 2 (4 dimethylaminobenzal)hydrazone Cytotoxicity Fibroblast cell viability liquid chromatography-mass spectrometry piperazine derivative Pharmacology chemistry.chemical_classification human cell drug cytotoxicity pyridazinone hydrazone derivative Colon cancer cell carbon nuclear magnetic resonance medicine.disease Molecular biology digestive system diseases unclassified drug medicine.anatomical_structure colon cancer 6 [4 (2 fluorophenyl)piperazine 1 yl] 3 (2h) pyridazinone 2 acetyl 2 (2 methoxybenzal)hydrazone chemistry Cell culture cytotoxic agent polymerization chemical structure cytotoxicity drug synthesis 6 [4 (2 fluorophenyl)piperazine 1 yl] 3 (2h) pyridazinone 2 acetyl 2 (4 bromobenzal)hydrazon pyridazinone derivative 6 [4 (2 fluorophenyl)piperazine 1 yl] 3 (2h) pyridazinone 2 acetyl 2 (4 methylbenzal)hydrazone Liver cancer
Popis:	In this study, seven new 3(2H)-pyridazinone derivatives expected to show cytotoxic activity in liver and colon cancer cell lines were synthesized. Their structures were confirmed by the IR, 1 H-NMR, 13 C-NMR spectra and elementary analyses. Compunds V 1 -V 7 were tested on HEP3B (liver cancer) and HTC116 (colon cancer) cell lines for cytotoxicity by using MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)- 2H-tetrazolium] proliferation assay. Human fibroblast cells were used as safety control in these tests. 6-[4-(2-Fluorophenyl)piperazine-1-yl]-3(2H)-pyridazinone-2-acetyl-2-(2-chlorobenzal)hydrazone (compound V 3 ) was the most active agent with respect to HEP3B and HTC116 cell lines. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Databáze:	OpenAIRE
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