Myocardial stiffness is an important determinant of the plasma brain natriuretic peptide concentration in patients with both diastolic and systolic heart failure
| Autor: | Junya Shite, Satoshi Watanabe, Daisuke Matsumoto, Hiromasa Otake, Hideyuki Takaoka, Oscar Luis Paredes, Daisuke Ogasawara, Mitsuhiro Yokoyama, Yusuke Imuro, Toshiro Shinke, Toru Ozawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Systole medicine.drug_class Diastole Hemodynamics Internal medicine Natriuretic Peptide Brain Blood plasma medicine Natriuretic peptide Humans cardiovascular diseases Pulmonary wedge pressure Aged Aged 80 and over Heart Failure Ejection fraction business.industry Stroke Volume Middle Aged medicine.disease Brain natriuretic peptide Myocardial Contraction Echocardiography Heart failure cardiovascular system Cardiology Female Cardiomyopathies Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Heart Journal. 27(7):832-838 |
| ISSN: | 0195-668X |
| Popis: | Aims Plasma brain natriuretic peptide (BNP) concentration increases in proportion to heart failure (HF) severity. Although plasma BNP decreases to a certain level by optimal treatment, there is significant heterogeneity in the baseline value among individuals. The underlying mechanism of the steady-state plasma BNP levels remains still controversial. We investigated the hypothesis that myocardial stiffness ( K m) is a major determinant of the plasma BNP level. Methods and results In 19 patients with diastolic HF [DHF; left ventricular ejection fraction (LVEF)≥45%], 18 with systolic HF (SHF; LVEF |
| Databáze: | OpenAIRE |
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