Immune components of early breastmilk: Association with maternal factors and with reported food allergy in childhood
| Autor: | Mikaïl Berdi, Blandine de Lauzon-Guillain, Karine Adel-Patient, Christophe Junot, Marie-Aline Charles, A. Forhan, François Fenaille, Florence Castelli, Barbara Heude |
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| Přispěvatelé: | Service de Pharmacologie et d'Immunoanalyse (SPI), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université Paris Saclay (COmUE), Université Sorbonne Paris Cité (COMUE) (USPC), Institut National de la Recherche Agronomique (INRA), Laboratoire d'Etude du Métabolisme des Médicaments (LEMM), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Médicaments et Technologies pour la Santé (MTS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Fondation pour la Recherche Medicale (FRM), French Ministry of Research: Federative Research Institutes and Cohort Program, INSERM Human Nutrition National Research Program, Diabetes National Research |
| Rok vydání: | 2019 |
| Předmět: |
eden mother-child cohort
[SDV]Life Sciences [q-bio] Immunology Immunoglobulins Mothers Physiology Cohort Studies Atopy 03 medical and health sciences 0302 clinical medicine Immune system Pregnancy early breastmilk Food allergy growth factors Humans Immunology and Allergy Medicine Prospective Studies 030212 general & internal medicine 2. Zero hunger food allergy Milk Human biology Gut barrier business.industry Infant Newborn immune factors medicine.disease 3. Good health 030228 respiratory system Pediatrics Perinatology and Child Health biology.protein Cytokines Intercellular Signaling Peptides and Proteins Female France Antibody business Birth cohort Food Hypersensitivity Medical doctor |
| Zdroj: | Pediatric Allergy and Immunology Pediatric Allergy and Immunology, Wiley, 2019, 30 (1), pp.107-116. ⟨10.1111/pai.12998⟩ Pediatric Allergy and Immunology, 2019, 30 (1), pp.107-116. ⟨10.1111/pai.12998⟩ |
| ISSN: | 0905-6157 1399-3038 |
| DOI: | 10.1111/pai.12998 |
| Popis: | International audience; Background Breastmilk (BM) may participate in driving gut barrier function and immunity in the neonate. We analyzed immune and growth factor concentrations in early BM and their association with maternal/environmental characteristics and with food allergy (FA) in childhood. Methods One BM sample was collected in maternity from some mothers in the EDEN birth cohort (n = 2002 mother-child dyads). A random selection was performed among available samples (subcohort, n = 272), for which all deliveries were full-term, various maternal/environmental characteristics were recorded, and parents answered yearly the question "Has a medical doctor diagnosed a FA in your child?" (26 parent-reported FA cases). Only samples collected between day 2 and day 6 post-partum were considered for descriptive analysis (n = 263). Samples for all other FA cases available were added to the subcohort (46 additional cases; "casecohort" design). Fifty cytokines, antibodies, and growth factor concentrations were determined using multiplexed kits and analyzed using robust statistical procedures. Results BM components exhibited wide concentration ranges and global day-to-day variation. Different clusters of correlated factors appeared, with components from the main cluster related to maternal diet during pregnancy. Primiparity was positively associated with eleven other components, whereas other factors (eg, maternal atopy and smoking) were related to fewer components. Finally, the casecohort design highlighted a positive association between CXCL10, TNF beta, and IL-2 concentrations and reported FA in childhood. Conclusion Beyond the unique description of early BM composition, we show that immune information transmitted to the neonate is related to various maternal factors and identified components associated with FA diagnosis in childhood. |
| Databáze: | OpenAIRE |
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