Choroidal and peripapillary changes in high myopic eyes with Stickler syndrome
| Autor: | Gilles Guerrier, Olivia Xerri, Pierre-Olivier Barale, Pierre-Raphaël Rothschild, Elise Philippakis, Sophie Valleix, Antoine P. Brézin, Olivier Laplace, Federico Bernabei, C. Monin, Dominique Bremond-Gignac, Cyril Burin-Des-Roziers |
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| Přispěvatelé: | Service d'ophtalmologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Cochin [AP-HP], Hôpital Lariboisière-Fernand-Widal [APHP], Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO), Unité de Soins Intensifs [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Gestionnaire, Hal Sorbonne Université |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty genetic structures Hearing Loss Sensorineural [SDV]Life Sciences [q-bio] Congenital myopia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Ophthalmology Ophthalmology High myopia medicine Humans In patient Stickler syndrome Peripapillary atrophy Connective Tissue Diseases Hereditary vitreopathy medicine.diagnostic_test Choroid business.industry Arthritis Retinal Detachment Fundus photography Retinal General Medicine medicine.disease eye diseases [SDV] Life Sciences [q-bio] 030104 developmental biology chemistry Choroidal thickness lcsh:RE1-994 030221 ophthalmology & optometry Lower prevalence Posterior staphyloma Maculopathy sense organs business Tomography Optical Coherence Research Article |
| Zdroj: | BMC Ophthalmology BMC Ophthalmology, BioMed Central, 2021, 21 (1), pp.2. ⟨10.1186/s12886-020-01777-3⟩ BMC Ophthalmology, Vol 21, Iss 1, Pp 1-7 (2021) |
| ISSN: | 1471-2415 |
| DOI: | 10.1186/s12886-020-01777-3⟩ |
| Popis: | Background To compare different clinical and Spectral-Domain Optical Coherence Tomography (SD-OCT) features of high myopic eyes with Stickler syndrome (STL) with matched controls. Methods Patients with genetically confirmed STL with axial length ≥ 26 mm and controls matched for axial length were included. The following data were obtained from SD-OCT scans and fundus photography: choroidal and retinal thickness (respectively, CT and RT), peripapillary atrophy area (PAA), presence of posterior staphyloma (PS). Results Twenty-six eyes of 17 patients with STL and 25 eyes of 19 controls were evaluated. Compared with controls, patients with STL showed a greater CT subfoveally, at 1000 μm from the fovea at both nasal and temporal location, and at 2000 and 3000 μm from the fovea in nasal location (respectively, 188.7±72.8 vs 126.0±88.7 μm, 172.5±77.7 vs 119.3±80.6 μm, 190.1±71.9 vs 134.9±79.7 μm, 141.3±56.0 vs 98.1±68.5 μm, and 110.9±51.0 vs 67.6±50.7 μm, always PP2, P=0.03), compared with controls. Conclusions This study shows that high myopic patients with STL show a greater CT, a lower PAA and a lower prevalence of PS, compared with controls matched for axial length. These findings could be relevant for the development and progression of myopic maculopathy in patients with STL. |
| Databáze: | OpenAIRE |
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