Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats
| Autor: | Zeynep Cirakli, Ozlem Bingol Ozakpinar, Erliasa Bami, Zarife Nigar Ozdemir-Kumral, Betül Okuyan, Turgut Şekerler, Fikret Izzettin, Feriha Ercan, Kutay Koroglu, Mesut Sancar |
|---|---|
| Přispěvatelé: | İZZETTİN, FIKRET VEHBI |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Curcumin Antioxidant Coumaric Acids Health Toxicology and Mutagenesis medicine.medical_treatment Pharmacology Kidney Protective Agents Toxicology medicine.disease_cause Blood Urea Nitrogen Nephrotoxicity Ferulic acid 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Malondialdehyde medicine Animals RNA Messenger Rats Wistar Peroxidase Cisplatin biology Nitrotyrosine General Medicine 030104 developmental biology chemistry Biochemistry 030220 oncology & carcinogenesis Myeloperoxidase Heme Oxygenase (Decyclizing) biology.protein Tyrosine Kidney Diseases Oxidative stress medicine.drug |
| Zdroj: | Environmental Toxicology and Pharmacology. 54:105-111 |
| ISSN: | 1382-6689 |
| DOI: | 10.1016/j.etap.2017.06.026 |
| Popis: | This study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels ( p 0.05 ). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals ( p 0.05 ). All parameters showed improvement in groups treated with ferulic acid ( p 0.05 ). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound. |
| Databáze: | OpenAIRE |
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