A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal
| Autor: | E. Zanaria, G. Camerino, E. Ferrante, Edward R. B. McCabe, Kim C. Worley, G. Chiumello, Barbara Bardoni, Giovanna Floridia, G. Tonini, M. Fraccaro, Orsetta Zuffardi, S. Guioli |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Genetic Markers
Male medicine.medical_specialty Sex Differentiation X Chromosome Locus (genetics) Biology Dosage Compensation Genetic Internal medicine X-linked adrenal hypoplasia congenita Testis Genetics medicine Humans X chromosome Dosage compensation business.industry Ovary Sexual differentiation in humans Chromosome Mapping Obstetrics and Gynecology General Medicine Sex reversal medicine.disease Phenotype Endocrinology Testis determining factor Multigene Family Female DAX1 business Male to female Gene Deletion |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1546-1718 1061-4036 |
| Popis: | Male to female sex reversal has been observed in individuals with duplications of the short arm of the X chromosome. Here we demonstrate that sex reversal results from the presence of two active copies of an Xp locus rather than from its rearrangement and that alterations at this locus constitute one of the causes of sex reversal in individuals with a normal 46,XY karyotype. We have named this locus DSS (Dosage Sensitive Sex reversal) and localized it to a 160 kilobase region of chromosome Xp21, adjacent to the adrenal hypoplasia congenita locus. The identification of male individuals deleted for DSS suggests that this locus is not required for testis differentiation. We propose that DSS has a role in ovarian development and/or functions as a link between ovary and testis formation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|