The role of growth hormone and insulin-like growth factors in the immune system
| Autor: | S C van Buul-Offers, Ron Kooijman |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Mice Transgenic Biology Insulin-like growth factor-binding protein Receptor IGF Type 1 Mice Cellular and Molecular Neuroscience Paracrine signalling Immune system Internal medicine medicine Animals Humans Endocrine system Growth factor receptor inhibitor Insulin-Like Growth Factor I Autocrine signalling Receptor Molecular Biology Pharmacology Growth factor Receptors Somatotropin Cell Biology Endocrinology Growth Hormone Immune System biology.protein Molecular Medicine |
| Zdroj: | Cellular and Molecular Life Sciences CMLS. 54:1083-1094 |
| ISSN: | 1420-9071 1420-682X |
| Popis: | Growth hormone (GH) and insulin-like growth factor I (IGF-I) can modulate the development and function of the immune system. In this chapter, we present data on the expression of receptors for GH and IGFs and the in vitro and in vivo effects of these proteins. We show that expression of GH and IGFs in the immune system opens up the possibility that these proteins are not only involved in endocrine control of the immune system but can also play a role as local growth and differentiation factors (cytokines). Endocrine control of GH could be direct or mediated via endocrine or autocrine/paracrine IGF-I. In addition, GH can act as an autocrine or paracrine factor itself. Furthermore, IGF-I in the immune system has been shown to be regulated by cytokines, such as interleukin-1 and interferon-gamma, alluding to a cytokine-like function of IGF-I. In addition to data on the function of GH and IGF-I in the immune system, we present new findings which imply a possible function of IGF-II and IGF-binding proteins. |
| Databáze: | OpenAIRE |
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